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Effects of paliperidone palmitate on coagulation: an experimental study.

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dc.contributor.authorYılmaz, Enver Demirel
dc.contributor.authorMotor, Sedat
dc.contributor.authorSefil, Fatih
dc.contributor.authorPınar, Neslihan
dc.contributor.authorKokacya, Hanifi
dc.contributor.authorKisa, Mustafa
dc.contributor.authorOktar, Suleyman
dc.date.accessioned2023-05-16T16:44:06Z
dc.date.available2023-05-16T16:44:06Z
dc.description.abstractThe aim of the present study was to examine the effects of a new antipsychotic drug paliperidone palmitate on hemogram and coagulation parameters in rats.
dc.description.abstractExperiments were performed on 22 female albino Wistar rats (8-12 weeks old). Control group was given drinking water as vehicle (0.3 mL). PAL-1 rats were given 1 mg/kg paliperidone palmitate (in 0.3 mL drinking water) by oral gavage once a day for ten days and PAL-3 rats received 3 mg/kg paliperidone palmitate (in 0.3 mL drinking water) by oral gavage for ten days. Blood samples were drawn from the heart 24 hours after the last drug dose, and hemogram and coagulation parameters were measured with automated analyzers.
dc.description.abstractHemogram did not change in the paliperidone treated groups compared to the controls. Factor VIII levels decreased in the PAL-1 and PAL-3 groups; and this decrease was significantly greater in the PAL-3. Factor IX levels decreased in PAL-3 rats, but its levels also increased in PAL-1 rats compared to the control.
dc.description.abstractPaliperidone has led to changes in the serum levels of coagulation factors VIII and IX in rats. As a result, paliperidone may be causing thromboembolism or bleeding in a dose-independent manner.
dc.identifier.pubmed24764772
dc.identifier.urihttps://hdl.handle.net/20.500.12645/38207
dc.language.isoen
dc.titleEffects of paliperidone palmitate on coagulation: an experimental study.
dspace.entity.typePublication
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