Publication:
Possible association of the 5-HTTLPR serotonin transporter promoter gene polymorphism with premature ejaculation in a Turkish population.

dc.contributor.authorOzbek, Emin
dc.contributor.authorTasci, Ali I
dc.contributor.authorTugcu, Volkan
dc.contributor.authorIlbey, Yusuf O
dc.contributor.authorSimsek, Abdulmuttalip
dc.contributor.authorOzcan, Levent
dc.contributor.authorPolat, Emre C
dc.contributor.authorKoksal, Vedat
dc.date.accessioned2023-05-16T17:08:45Z
dc.date.available2023-05-16T17:08:45Z
dc.date.issued2009-04-30T21:00:00Z
dc.description.abstractWe evaluated the genotypes of the serotonin transporter gene (5-HTT) in patients with premature ejaculation (PE) to determine the role of genetic factors in the etiopathogenesis of PE and possibly to identify the patient subgroups. A total of 70 PE patients and 70 controls were included in this study. All men were heterosexual, had no other disorders and were either married or in a stable relationship. PE was defined as ejaculation that occurred within 1 min of vaginal intromission. Genomic DNA from patients and controls was analyzed using polymerase chain reaction, and allelic variations of the promoter region of the serotonin transporter gene (5-HTTLPR) were determined. The 5-HTTLPR (serotonin transporter promoter gene) genotypes in PE patients vs. controls were distributed as follows: L/L 16% vs. 17%, L/S 30% vs. 53% and S/S 54% vs. 28%. We examined the haplotype analysis for three polymorphisms of the 5-HTTLPR gene: LL, LS and SS. The appropriateness of the allele frequencies in the 5-HTTLPR gene was analyzed by the Hardy-Weinberg equilibrium using the chi2-test. The short (S) allele of the 5-HTTLPR gene was significantly more frequent in PE patients than in controls (P<0.05). We suggest that the 5-HTTLPR gene plays a role in the pathophysiology of all primary PE cases. Further studies are needed to evaluate the relationship between 5-HTTLPR gene polymorphism and patient subgroup (such as primary and secondary PE) responses to selective serotonin reuptake inhibitors as well as ethnic differences.
dc.identifier.pubmed19252508
dc.identifier.urihttps://hdl.handle.net/20.500.12645/38287
dc.language.isoen
dc.titlePossible association of the 5-HTTLPR serotonin transporter promoter gene polymorphism with premature ejaculation in a Turkish population.
dspace.entity.typePublication
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