Publication:
Assessment of in vitro cytotoxic and genotoxic activities of some trimethoprim conjugates

Simple item page
dc.contributor.authorBayulken, Devrim Guzel
dc.contributor.authorBostancioglu, R. Beklem
dc.contributor.authorKoparal, A. Tansu
dc.contributor.authorTuylu, Berrin Ayaz
dc.contributor.authorDag, AYDAN
dc.contributor.authorBenkli, KADRİYE
dc.contributor.institutionauthorDAĞ, AYDAN
dc.contributor.institutionauthorBENKLİ, KADRIYE
dc.date.accessioned2019-10-05T13:12:16Z
dc.date.available2019-10-05T13:12:16Z
dc.date.issued2018-06-01
dc.description.abstractTrimethoprim, a commonly used antibacterial agent, is widely applied in the treatment of variety of infections in human. A few studies have demonstrated an extensive exposure of man to antibiotics, but there is still a lack of data for cytotoxic effects including nephrotoxicity, gastrointestinal toxicity, hematotoxicity, neurotoxicity and ototoxicity. The main purpose behind this study was to determine cytotoxic and genotoxic activities of trimethoprim (1), trimethoprim with maleic acid (2) and trimethoprim in conjugation with oxalic acid dihydrate (3). The cytotoxic effects of these three conjugates were elucidated by employing 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoium bromide (MTT) assay using embryonic rat fibroblast-like cell line (F2408) and H-ras oncogene activated embryonic rat fibroblast-like cancer cell line (5RP7). Additionally, determination of genotoxic activity of these three compounds were studied by using cytokinesis blocked micronucleus assay (CBMN) in human lymphocytes. The results demonstrated that trimethoprim alone and its combination with other compounds are able to induce both cytotoxic and genotoxic damage on cultured cells (F2408, 5RP7, human lymphocytes).en
dc.identifier10.1007/s11845-014-1219-8
dc.identifier.citationBayulken D. G. , Bostancioglu R. B. , Koparal A. T. , Tuylu B. A. , Dag A., Benkli K., -Assessment of in vitro cytotoxic and genotoxic activities of some trimethoprim conjugates-, CYTOTECHNOLOGY, cilt.70, ss.1051-1059, 2018
dc.identifier.doi10.1007/s10616-018-0187-7
dc.identifier.pubmed29335807
dc.identifier.scopus85041654125
dc.identifier.urihttps://hdl.handle.net/20.500.12645/1591
dc.identifier.wosWOS:000436566500016
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleAssessment of in vitro cytotoxic and genotoxic activities of some trimethoprim conjugates
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameIRISH JOURNAL OF MEDICAL SCIENCE
local.avesis.id25e10da3-8b6f-4ec7-a6a8-4bbeac3b7e63
local.avesis.response1461
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isAuthorOfPublication5053fdfd-57cd-423a-9076-db4bab8cbe3d
relation.isAuthorOfPublication7c79666b-9d7a-4020-a3f2-da0a94989b66
relation.isAuthorOfPublication.latestForDiscovery7c79666b-9d7a-4020-a3f2-da0a94989b66
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
64- Assessment of in vitro cytotoxic and genotoxic activities of some trimethoprim conjugates.pdf
Size:
475.38 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Yayınlar - Eserler
Eczacılık Fakültesi