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The effects of maternal smoking on fetal cranial development. Findings from routine midtrimester sonographic anomaly screening

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dc.contributor.authorÇETİN Ç.
dc.contributor.authorBAKAR R. Z.
dc.contributor.authorTakmaz T.
dc.contributor.authorPASİN Ö.
dc.contributor.authorKÜTÜK M. S.
dc.contributor.institutionauthorÇETİN, ÇAĞLAR
dc.contributor.institutionauthorBAKAR, RABIA ZEHRA
dc.contributor.institutionauthorPASİN, ÖZGE
dc.contributor.institutionauthorKÜTÜK, MEHMET SERDAR
dc.date.accessioned2023-02-22T21:30:32Z
dc.date.available2023-02-22T21:30:32Z
dc.date.issued2023-12-01
dc.description.abstractThe aim of this study was to assess the effect of continued smoking before and during pregnancy on mid-trimester fetal head development. A total of 250 pregnant women enrolled in the study. All participants were confirmed to be smokers or non-smokers by verifying breath carbon monoxide readings. Biparietal diameter (BPD), head circumference (HC), lateral ventricle (LV), and cisterna magna (CM) were evaluated by ultrasound between 20-22 weeks of pregnancy. Gender and gestational age-adjusted BPD z- scores were not statistically different between smokers and non-smokers (-0.75 ± 1.6 vs -0.51 ± 1, p = .3). HC measurements and z- scores were significantly lower in the smoking group than in the non-smoking groups (183.38 ± 14.56 vs. 189.28 ± 12.53, p = .003, 0.18 ± 1.39 multiple of median (MoM) vs. 0.56 ± 0.92, respectively, p = .023). At linear regression analysis, maternal smoking was the only independent factor associated with fetal HC z score (p = .041). In conclusion, continued smoking during pregnancy reduces fetal HC and has no effect on BPD, LV, or CM measurements at mid-gestation.IMPACT STATEMENTWhat is already known on this subject? Smoking during pregnancy is one of the most common environmental factors affecting fetal and neonatal growth and well-being. Despite the well-known effects of smoking on somatic growth, current studies have shown that it selectively affects some parts of the fetal brain, even in appropriately growing fetuses.What do the results of this study add? Continued smoking during pregnancy reduces fetal HC and has no effect on BPD, LV or CM measurements at mid-gestation. Since smoking is well known for its early and late childhood behavioral and neurological consequences, smaller mid-trimester fetal HC measurements should bring maternal smoking to mind as one of the potentially reversible causes.What are the implications of these findings for clinical practice and/or further research? The harmful effects of smoking start before the third trimester and antenatal counseling should be started early in the gestation. Every effort should be made to quit smoking before or early in pregnancy.
dc.identifier.citationÇETİN Ç., BAKAR R. Z., Takmaz T., PASİN Ö., KÜTÜK M. S., "The effects of maternal smoking on fetal cranial development. Findings from routine midtrimester sonographic anomaly screening", Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, cilt.43, sa.1, ss.2176205, 2023
dc.identifier.doi10.1080/01443615.2023.2176205
dc.identifier.endpage2176205
dc.identifier.issn1364-6893
dc.identifier.issue1
dc.identifier.pubmed36772953
dc.identifier.startpage2176205
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85147893553&origin=inward
dc.identifier.urihttps://hdl.handle.net/20.500.12645/37095
dc.identifier.volume43
dc.relation.ispartofJournal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectCerrahi Tıp Bilimleri
dc.subjectKadın Hastalıkları ve Doğum
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectSurgery Medicine Sciences
dc.subjectObstetrics and Gynecology
dc.subjectHealth Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectKADIN HASTALIKLARI & DOĞUM
dc.subjectClinical Medicine (MED)
dc.subjectCLINICAL MEDICINE
dc.subjectOBSTETRICS & GYNECOLOGY
dc.subjectDoğum ve Jinekoloji
dc.subjectBreath carbon monoxide
dc.subjectfetal cranial measurements
dc.subjectfetal development
dc.subjectpregnancy
dc.subjectsmoking
dc.subjectultrasound
dc.titleThe effects of maternal smoking on fetal cranial development. Findings from routine midtrimester sonographic anomaly screening
dc.typearticle
dspace.entity.typePublication
local.avesis.id0c44dcfd-584a-4de8-b5a2-4e303a74aa4a
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
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