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Apoptotic, antioxidant and antiradical effects of majdine and isomajdine from Vinca herbacea Waldst. and kit

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dc.contributor.authorGÜLÇİN, İlhami
dc.contributor.authorBeydemir, Sukru
dc.contributor.authorTopal, Fevzi
dc.contributor.authorGagua, Natia
dc.contributor.authorBakuridze, Aliko
dc.contributor.authorBayram, Recep
dc.contributor.authorGepdiremen, ALİ AKÇAHAN
dc.contributor.institutionauthorGEPDİREMEN, ALİ AKÇAHAN
dc.date.accessioned2020-10-29T23:56:51Z
dc.date.available2020-10-29T23:56:51Z
dc.date.issued2012-08-01T00:00:00Z
dc.description.abstractIn the present study, apoptotic, antioxidant and antiradical effects of majdine and isomajdine from Vinca herbacea Waldst. and Kit were studied. For testing the possible apoptotic effects of majdine and isomajdine from V. herbacea, DNA fragmentation assay was conducted on the rat brain cortical tissue homogenates, in vitro. Also their possible effects on mitochondrial activity were tested by using the same tissue samples of rats. In addition, the antioxidant activity of isomajdine and majdine was determined using various in vitro antioxidant assays, including 2,2--azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS(center dot+)) radical scavenging and N,N-dimethyl-p-phenylenediamine (DMPD center dot+) radical scavenging, ferric ions (Fe3+) and cupric ions (Cu2+) reducing abilities and ferrous ions (Fe2+) chelating activity. On the other hand, butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), alpha-tocopherol and trolox (6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid) were used as reference antioxidants.
dc.identifier.citationGÜLÇİN İ., Beydemir S., Topal F., Gagua N., Bakuridze A., Bayram R., Gepdiremen A. A. , -Apoptotic, antioxidant and antiradical effects of majdine and isomajdine from Vinca herbacea Waldst. and kit-, JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, cilt.27, ss.587-594, 2012
dc.identifier.doi10.3109/14756366.2011.604318
dc.identifier.scopus84864048634
dc.identifier.urihttp://hdl.handle.net/20.500.12645/27060
dc.identifier.wosWOS:000306524200017
dc.titleApoptotic, antioxidant and antiradical effects of majdine and isomajdine from Vinca herbacea Waldst. and kit
dc.typeArticle
dspace.entity.typePublication
local.avesis.ide45457ca-0d43-4710-8116-edd0149ea72e
local.publication.isinternational1
relation.isAuthorOfPublicationdc70adc1-eb72-4820-8b6d-4b39285a568f
relation.isAuthorOfPublication.latestForDiscoverydc70adc1-eb72-4820-8b6d-4b39285a568f
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