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Epidemiological and molecular characteristics of meticillin-resistant Staphylococcus aureus in Turkey: A multicentre study

dc.contributor.authorDÜNDAR, DEVRİM
dc.contributor.authorWillke, Ayse
dc.contributor.authorSAYAN, MURAT
dc.contributor.authorKoc, MELİHA
dc.contributor.authorAkan, Ozay Arikan
dc.contributor.authorSUMERKAN, Bulent
dc.contributor.authorSaltoglu, Nese
dc.contributor.authorYAMAN, AKGÜN
dc.contributor.authorAyaz, Celal
dc.contributor.authorKoksal, Iftihar
dc.contributor.institutionauthorMERİÇ KOÇ, MELİHA
dc.date.accessioned2020-10-29T12:47:30Z
dc.date.available2020-10-29T12:47:30Z
dc.date.issued2016-09-01T00:00:00Z
dc.description.abstractThe aim of this study was to investigate the epidemiological and molecular features of clinical meticillin-resistant Staphylococcus aureus (MRSA) isolates in Turkey. MRSA isolates were collected from six regions of Turkey. The mecA and nuc genes were detected by PCR. Antimicrobial susceptibilities were determined by the disk diffusion method. Staphylococcal cassette chromosome mec (SCCmec) and staphylococcal protein A (spa) typing were performed by the sequencing method for 270 randomly selected MRSA isolates. The US Centers for Disease Control and Prevention (CDC) definition was used for epidemiological diagnosis of community-associated MRSA (CA-MRSA). Resistance rates of MRSA to ciprofloxacin, gentamicin, clindamycin, erythromycin, rifampicin, trimethoprim/sulfamethoxazole and tetracycline were 93.4%, 81.2%, 38.5%, 57.8%, 93.9%, 1.1% and 93.1%, respectively. The most frequent SCCmec type was SCCmec III (91.1%). SCCmec type IV was found in 5.2% of the isolates. The most frequent spa type was t030 (81.1%). Five isolates were CA-MRSA if only the epidemiological definition was used (5/725; 0.7%). Two isolates were defined as CA-MRSA both by epidemiological features and SCCmec typing (2/270; 0.7%). Of 14 SCCmec type IV isolates, 12 were not defined as CA-MRSA by epidemiological features. In conclusion, this is the most comprehensive multicentre study in Turkey investigating MRSA using both epidemiological and genotypic features. The CA-MRSA rate is low in Turkey. Combined use of epidemiological and genotypic methods is the most accurate approach for the diagnosis of CA-MRSA. (C) 2016 International Society for Chemotherapy of Infection and Cancer. Published by Elsevier Ltd. All rights reserved.
dc.identifier.citationDÜNDAR D., Willke A., SAYAN M., Koc M., Akan O. A. , SUMERKAN B., Saltoglu N., YAMAN A., Ayaz C., Koksal I., -Epidemiological and molecular characteristics of meticillin-resistant Staphylococcus aureus in Turkey: A multicentre study-, JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE, cilt.6, ss.44-49, 2016
dc.identifier.doi10.1016/j.jgar.2016.02.006
dc.identifier.scopus84962892969
dc.identifier.urihttp://hdl.handle.net/20.500.12645/25044
dc.identifier.wosWOS:000381918100009
dc.titleEpidemiological and molecular characteristics of meticillin-resistant Staphylococcus aureus in Turkey: A multicentre study
dc.typeArticle
dspace.entity.typePublication
local.avesis.id014578d5-4806-442d-bd66-cad29bc30734
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
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