Publication:
MEFV mutation frequencies in a Turkish cohort with low prevalence of familial Mediterranean fever.

No Thumbnail Available
Date
2021-08-29T21:00:00Z
Authors
Authors
Çakır, Necati
Azaklı, Hülya
Üstek, Duran
Uysal, Ömer
Gözke, Eren
Journal Title
Journal ISSN
Volume Title
Publisher
Research Projects
Organizational Units
Journal Issue

Metrics

Search on Google Scholar

Abstract
Familial Mediterranean fever (FMF) is a genetically recessive autoinflammatory disease caused by mutations in the Mediterranean fever (MEFV) gene. The aim of this study was to investigate the frequencies of the most common MEFV mutations among a sample of healthy individuals from the Havsa population of European Turkey, where FMF is less prevalent compared to Asian Turkey.
The study group consisted of 263 unrelated healthy adults. All of the participants were analyzed for the M694V, V726A, M680I, and E148Q mutations in the MEFV gene.
In total, 25 of the 263 individuals carried MEFV mutations (9.5%). The observed allele frequencies were 1.5% for M694V (95% confidence interval [CI] 0.5-2.5), 2.6% for E148Q (95% CI 1.6-3.9), 0.5% for M680I (95% CI 0.0-1.1), and 0.0% for V726A. The frequencies of the M694V, M680I, and E148Q mutations were not significantly different from allele frequencies (approximately 20%) determined for other regions of Turkey where FMF is more prevalent.
These data suggest that the positivity of the MEFV gene mutation tests have lower predictive value in a population with low FMF prevalence.
Description
Keywords
Familial Mediterranean fever, MEFV gene, mutations
Citation
Page Views

0

File Downloads

0

Sustainable Development Goals