Publication: Peri-operative radiotherapy for the prevention of post -operative fibrosis on rats
dc.contributor.author | KIZILTAN, HURİYE ŞENAY | |
dc.contributor.author | ERIS, ALİ HİKMET | |
dc.contributor.author | MERAL, İSMAİL | |
dc.contributor.author | SEYİTHANOĞLU, HAKAN | |
dc.contributor.author | DÜNDAR, TOLGA TURAN | |
dc.contributor.author | EREN, FATMA | |
dc.contributor.author | ÜNVER, NURCAN | |
dc.contributor.author | AYDIN, TEOMAN | |
dc.contributor.author | MAYADAGLı, ALPASLAN | |
dc.contributor.institutionauthor | KIZILTAN, HURİYE ŞENAY | |
dc.contributor.institutionauthor | ERİŞ, ALİ HİKMET | |
dc.contributor.institutionauthor | MERAL, İSMAİL | |
dc.contributor.institutionauthor | SEYİTHANOĞLU, MEHMET HAKAN | |
dc.contributor.institutionauthor | DÜNDAR, TOLGA TURAN | |
dc.contributor.institutionauthor | ÜNVER, NURCAN | |
dc.contributor.institutionauthor | AYDIN, TEOMAN | |
dc.contributor.institutionauthor | MAYADAĞLI, ALPASLAN | |
dc.date.accessioned | 2019-10-05T15:02:52Z | |
dc.date.available | 2019-10-05T15:02:52Z | |
dc.date.issued | 2018-10-01 | |
dc.description.abstract | Background: Post-operative fibrosis related pains and functional anomalies can be serious problems for patients. Radiotherapy (RT) could inhibit fibrosis which may occurs post- operation especially following laminectomy. Therefore, this study was designed to investigate the effect of peri-operative RT on the prevention of post-operative fibrosis and scar formation on rats. Materials and Methods: Twenty three male Wistar albino rats, were divided into three experimental groups. Laminectomy was performed to L3 and L4 lomber vertebral regions of group L and L+R rats. The rats in L+R group in addition to this procedure also received ped-operative RT on the laminectomy area. A total dose of 700 cGy of RT was applied as a single fraction using electrons. Control rats received no treatment. A rotarod test was performed at 20, 30 and 40 rpm/min speed rates to determine the physical performances of the rats. Results: The results have indicated statistically significant (P<0.05) differences for the 30 rpm/min rotarod test between the L and L+R groups. Histopatologically, significant differences were observed in epidural fibrosis, fibroblast cell density and arachnoid adhesion between the L and L+R groups. Conclusion: It was concluded that ped-operative RT may provide a significant advantage for prevention post-laminectomic of scar tissue formation. | |
dc.identifier | 10.4274/npa.y5785 | |
dc.identifier.citation | KIZILTAN H. Ş. , ERIS A. H. , MERAL İ., SEYİTHANOĞLU H., DÜNDAR T. T. , EREN F., ÜNVER N., AYDIN T., MAYADAGLı A., GÜNEŞ BAYIR A., et al., -Peri-operative radiotherapy for the prevention of post -operative fibrosis on rats-, INTERNATIONAL JOURNAL OF RADIATION RESEARCH, cilt.16, ss.482-485, 2018 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12645/5313 | |
dc.language.iso | en | |
dc.title | Peri-operative radiotherapy for the prevention of post -operative fibrosis on rats | |
dc.type | Article | |
dspace.entity.type | Publication | |
local.article.journalname | NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY | |
local.avesis.id | 82880bfe-755b-46bb-8d97-0a83d5d65c82 | |
local.avesis.response | 5183 | |
local.org.faculty | Tıp Fakültesi | |
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