Publication: Real-world treatment outcomes from nationwide Onco-colon Turkey registry in RAS wild-type patients treated with biologics second-line mCRC
dc.contributor.author | Yildirim M. E. | |
dc.contributor.author | Karadurmus N. | |
dc.contributor.author | Okten I. N. | |
dc.contributor.author | TÜRK H. M. | |
dc.contributor.author | Urakci Z. | |
dc.contributor.author | Arslan C. | |
dc.contributor.author | Celik S. | |
dc.contributor.author | DANE F. | |
dc.contributor.author | ŞENDUR M. A. N. | |
dc.contributor.author | BİLİR C. | |
dc.contributor.author | et al. | |
dc.contributor.institutionauthor | TÜRK, HACI MEHMET | |
dc.date.accessioned | 2024-05-07T21:50:18Z | |
dc.date.available | 2024-05-07T21:50:18Z | |
dc.date.issued | 2024-04-13 | |
dc.description.abstract | Backgrounds and Objectives Colorectal cancer is one of the leading causes of mortality both globally and in our country. In Turkey, we conducted a multicenter investigation into the effectiveness of second-line treatments and real-life data for patients with RAS wild-type metastatic colorectal cancer (NCT04757311).Materials and Methods In this retrospective analysis, records from 28 centers were collected, and histopathological, molecular, and clinical characteristics were documented. Patients were categorized into groups based on their second-line biological treatments: anti-EGFR (Group A and Group B, panitumumab and cetuximab) and anti-VEGF (Group C, bevacizumab and aflibercept). They were then compared within these groups.Results A total of 588 patients with documented RAS wild-type status were evaluated. The median OS was 15.7, 14.3 and 14.7 months in Group A, Group B and Group C, respectively (p = 0.764). The median PFS of the patients in second-line setting that received panitumumab, cetuximab and bevacizumab/aflibercept were 7.8, 6.6 and 7.4 months, respectively (p = 0.848).Conclusion According to the results of our real-life data study, there is no significant difference in efficiency between the combination of biological agent and chemotherapy used in the second-line treatments. | |
dc.identifier.citation | Yildirim M. E., Karadurmus N., Okten I. N., TÜRK H. M., Urakci Z., Arslan C., Celik S., DANE F., ŞENDUR M. A. N., BİLİR C., et al., "Real-world treatment outcomes from nationwide Onco-colon Turkey registry in RAS wild-type patients treated with biologics second-line mCRC", JOURNAL OF ONCOLOGY PHARMACY PRACTICE, 2024 | |
dc.identifier.doi | 10.1177/10781552241241004 | |
dc.identifier.issn | 1078-1552 | |
dc.identifier.pubmed | 38613329 | |
dc.identifier.scopus | 85190527263 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12645/39260 | |
dc.identifier.wos | WOS:001201466900001 | |
dc.relation.ispartof | JOURNAL OF ONCOLOGY PHARMACY PRACTICE | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Tıp | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | İç Hastalıkları | |
dc.subject | Onkoloji | |
dc.subject | Eczacılık | |
dc.subject | Temel Eczacılık Bilimleri | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Temel Bilimler | |
dc.subject | Medicine | |
dc.subject | Internal Medicine Sciences | |
dc.subject | Internal Diseases | |
dc.subject | Oncology | |
dc.subject | Pharmacology and Therapeutics | |
dc.subject | Basic Pharmaceutics Sciences | |
dc.subject | Life Sciences | |
dc.subject | Health Sciences | |
dc.subject | Natural Sciences | |
dc.subject | ONKOLOJİ | |
dc.subject | Klinik Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | FARMAKOLOJİ VE ECZACILIK | |
dc.subject | Farmakoloji ve Toksikoloji | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | ONCOLOGY | |
dc.subject | CLINICAL MEDICINE | |
dc.subject | Clinical Medicine (MED) | |
dc.subject | PHARMACOLOGY & PHARMACY | |
dc.subject | PHARMACOLOGY & TOXICOLOGY | |
dc.subject | Life Sciences (LIFE) | |
dc.subject | Farmakoloji | |
dc.subject | Farmakoloji, Toksikoloji ve Eczacılık (çeşitli) | |
dc.subject | Genel Farmakoloji, Toksikoloji ve Eczacılık | |
dc.subject | Farmakoloji (tıbbi) | |
dc.subject | İlaç Rehberleri | |
dc.subject | Pharmacy | |
dc.subject | Pharmacology | |
dc.subject | Pharmacology, Toxicology and Pharmaceutics (miscellaneous) | |
dc.subject | General Pharmacology, Toxicology and Pharmaceutics | |
dc.subject | Pharmacology (medical) | |
dc.subject | Drug Guides | |
dc.title | Real-world treatment outcomes from nationwide Onco-colon Turkey registry in RAS wild-type patients treated with biologics second-line mCRC | |
dc.type | Article | |
dspace.entity.type | Publication | |
local.avesis.id | f2fa107b-2fe6-4452-ad88-4576b1b6710a | |
relation.isAuthorOfPublication | 1b3a1540-7e57-405d-8a9d-f926d17dcc29 | |
relation.isAuthorOfPublication.latestForDiscovery | 1b3a1540-7e57-405d-8a9d-f926d17dcc29 |