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Analytical tools for greenness assessment of chromatographic approaches: Application to pharmaceutical combinations of Indapamide, Perindopril and Amlodipine

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dc.contributor.authorSaleh, Sarah S.
dc.contributor.authorLotfy, Hayam M.
dc.contributor.authorTiris, GİZEM
dc.contributor.authorErk, Nevin
dc.contributor.authorRostom, Yasmin
dc.contributor.institutionauthorTIRIS, GİZEM
dc.date.accessioned2021-02-25T20:59:04Z
dc.date.available2021-02-25T20:59:04Z
dc.date.issued2020-12-01T00:00:00Z
dc.description.abstractThe green profile of the proposed method was assessed and compared with reported classical methods via four tools of greenness which are: Eco-Scale, National Environmental Methods Index (NEMI), Assessment of Green Profile (AGP) and Green Analytical Procedure Index (GAPI). A simple, precise and rapid (RP-HPLC) has been developed for the quantification of Indapamide (IND), perindopril (PER) arginine and amlodipine besylate (ADB) in binary and ternary mixtures. A greener alternate RP-HPLC method was presented for the determination of pharmaceutical combinations composed of the cited medications using an eco-friendly eluent and quick run time with the least waste yield. Chromatographic separation was achieved using Waters Spherisorb ODS-2 C18 column (150 x 4.6 mm, i.d., 5 mu m) and eluent formed of acetonitrile : phosphate buffer (20 mM, pH = 3): methanol in the ratio of (65: 30: 5, by volume) at flow rate 1.0 mL/min with DAD-detection at 220 nm. This procedure was valid over linearity ranges of 0.5-20 mu g/mL, 2.5-40 mu g/mL and 2-40 mu g/mL for IND, PER and AML, respectively. The presented chromatographic method was completely validated regarding ICH guidelines and were statistically compared with those of the reported methods applying t-test and F-test at 95% confidence. The proposed method was found to be greener in terms of usage of hazardous chemicals and solvents, energy consumption, and waste production.
dc.identifier.citationSaleh S. S. , Lotfy H. M. , Tiris G., Erk N., Rostom Y., -Analytical tools for greenness assessment of chromatographic approaches: Application to pharmaceutical combinations of Indapamide, Perindopril and Amlodipine-, MICROCHEMICAL JOURNAL, cilt.159, 2020
dc.identifier.doi10.1016/j.microc.2020.105557
dc.identifier.scopus85091806086
dc.identifier.urihttp://hdl.handle.net/20.500.12645/28486
dc.identifier.wosWOS:000598237600005
dc.titleAnalytical tools for greenness assessment of chromatographic approaches: Application to pharmaceutical combinations of Indapamide, Perindopril and Amlodipine
dc.typeArticle
dspace.entity.typePublication
local.avesis.ide7b16b4b-a928-4814-b700-7e6eeb066371
local.publication.goal07 - Erişilebilir ve Temiz Enerji
local.publication.isinternational1
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relation.isAuthorOfPublication.latestForDiscovery1ab47475-d54a-4b46-a679-47fb775bc1ce
relation.isGoalOfPublication0d527674-fd4e-41fa-b039-c51ba5faa6e5
relation.isGoalOfPublication.latestForDiscovery0d527674-fd4e-41fa-b039-c51ba5faa6e5
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