Publication: Candida albicans outbreak associated with total parenteral nutrition in the neonatal unit
dc.contributor.author | Güdücüoğlu, Hüseyin | |
dc.contributor.author | Gultepe, BİLGE | |
dc.contributor.author | OTLU, BARIŞ | |
dc.contributor.author | BEKTAS, A. | |
dc.contributor.author | YILDIRIM, OĞUZHAN | |
dc.contributor.author | Tuncer, Oğuz | |
dc.contributor.author | BERKTAS, M. | |
dc.contributor.institutionauthor | SÜMBÜL, BİLGE | |
dc.date.accessioned | 2019-10-05T14:23:45Z | |
dc.date.available | 2019-10-05T14:23:45Z | |
dc.date.issued | 2016-04-01 | |
dc.description.abstract | Background: The most frequently isolated fungi in patients using TPN belongs to the Candida genus. Various infections including venous catheter infections, fungemia, endocarditis and ophthalmitis may be encountered. Objective: Upon growth of Candida in the blood cultures from the pediatric (neonatal) unit of our hospital, a surveillance was performed in this unit and involving the health care workers. Clonal relationships of the isolates were investigated with molecular tests. Methods: Blood samples obtained from the patients in pediatric neonatal unit were studied with automatized blood culture [BacT/Alert (Bio Merioux, France)]. Yeast isolates from environmental surveillance cultures (TPN solutions, hands of healthcare personnel, etagere, etc) and patients were identified as C. albicans with conventional methods and ID 32 C and ATB (TM) Fungus 3 (Biomerieux, France) kits. Clonal similarity was determined by using AP-PCR as initial method and we have also typified all strains by the method of REP-PCR (diversilab system, bioMerieux). Finally; Pulsed Field Gel Electrophoresis (PFGE) was used for confirmation. Results: C. albicans was isolated in blood cultures of seven patients. Similar antifungal susceptibility patterns were observed in all isolates. AP-PCR and REP-PCR showed that the C. albicans isolates grown in the TPN solution and from the patients- blood cultures were clonally same strains. PFGE analysis further confirmed this clonality. Conclusion: According to results of the molecular methods, we thought that a C. albicans outbreak had occurred in the neonatal pediatric unit, due to contamination of TPN solution. | |
dc.identifier | ||
dc.identifier.citation | Güdücüoğlu H., Gultepe B., OTLU B., BEKTAS A., YILDIRIM O., Tuncer O., BERKTAS M., -Candida albicans outbreak associated with total parenteral nutrition in the neonatal unit-, INDIAN JOURNAL OF MEDICAL MICROBIOLOGY, cilt.34, ss.202-207, 2016 | |
dc.identifier.doi | 10.4103/0255-0857.180303 | |
dc.identifier.scopus | 84969758883 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12645/3763 | |
dc.identifier.wos | WOS:000378536300014 | |
dc.language.iso | en | |
dc.title | Candida albicans outbreak associated with total parenteral nutrition in the neonatal unit | |
dc.type | Article | |
dspace.entity.type | Publication | |
local.article.journalname | dişhekimliği dergisi | |
local.avesis.id | 5b34044c-a131-4806-80bb-ab4d66c25ef5 | |
local.avesis.response | 3633 | |
local.indexed.at | WOS | |
local.indexed.at | Scopus | |
local.publication.isinternational | 1 | |
relation.isAuthorOfPublication | 51568f47-69f1-46a2-b201-e6d6161080a8 | |
relation.isAuthorOfPublication.latestForDiscovery | 51568f47-69f1-46a2-b201-e6d6161080a8 |
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