Publication:
Increased Colostral Concentration of Macrophage Migration Inhibitory Factor in Mothers with Premature Rupture of Membranes

Simple item page
dc.contributor.authorBayraktar, Sueleyman
dc.contributor.authorTanyeri-Bayraktar, Bilge
dc.contributor.authorKilic, Uelkan
dc.date.accessioned2022-03-08T20:59:05Z
dc.date.available2022-03-08T20:59:05Z
dc.date.issued2022-02-01T00:00:00Z
dc.description.abstractObjective: The colostrum contains macrophage migration inhibitory factor (MIF), which plays an important role in protecting newborns from infections. As such, colostrum may be specifically important to prevent early onset neonatal sepsis among neonates born after premature rupture of membranes (PROM). However, the effect of PROM on the colostral MIF concentration has not been previously described. The aim of this study is to compare the concentration of MIF in the colostrum of mothers with and without PROM.Methods: The study group consisted of 44 women, 22 of whom had PROM. Colostrum was expressed and collected within 72 hours of birth. MIF concentration was measured using the enzyme-linked immunosorbent assay method and compared between mothers with and without PROM.Results: There were no differences between the two groups (PROM group n = 22, control group n = 22) with regard to the age of mothers, mode of delivery, neonatal gestational age, birth weight, and sex of the infants (p > 0.05). The colostral MIF concentration was significantly higher among mothers with than without PROM (p = 0.0001). There was a positive and significant correlation between the colostral MIF concentration and PROM duration (r = 0.314, p = 0.038).Conclusions: PROM was associated with a higher colostral MIF concentration, with this concentration being positively correlated with the duration of PROM. This increased concentration may be important in offering these neonates additional protection against early onset infections, which is a risk associated with PROM.
dc.identifier.citationBayraktar S., Tanyeri-Bayraktar B., Kilic U., -Increased Colostral Concentration of Macrophage Migration Inhibitory Factor in Mothers with Premature Rupture of Membranes-, BREASTFEEDING MEDICINE, cilt.17, sa.2, ss.189-193, 2022
dc.identifier.doi10.1089/bfm.2021.0190
dc.identifier.pubmed35049342
dc.identifier.scopus85124635915
dc.identifier.urihttp://hdl.handle.net/20.500.12645/30431
dc.identifier.wosWOS:000757564200013
dc.titleIncreased Colostral Concentration of Macrophage Migration Inhibitory Factor in Mothers with Premature Rupture of Membranes
dc.typeArticle
dspace.entity.typePublication
local.avesis.id948f8302-5b94-49e1-a031-3dc3c3f3e986
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
Files
Collections
Yayınlar - Eserler