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Healing of Ischemic Colon Anastomosis in Rats Could Be Provided by Administering Dexpanthenol or Coenzyme Q10

dc.contributor.authorPEHLİVANLI, FARUK
dc.contributor.authorAYDIN, OKTAY
dc.contributor.authorKARACA, GÖKHAN
dc.contributor.authorAYDIN, GÜLÇİN
dc.contributor.authorDEVRİM, TUBA
dc.contributor.authorBULUT, Huri
dc.contributor.authorBAKAR, BÜLENT
dc.contributor.authorDAPHAN, ÇAĞATAY ERDEN
dc.contributor.institutionauthorBULUT, HURI
dc.date.accessioned2020-10-29T14:55:46Z
dc.date.available2020-10-29T14:55:46Z
dc.date.issued2018-07-01T00:00:00Z
dc.description.abstractBackground: In this study, the effectiveness of dexpanthenol and coenzyme Q10 (CoQ10) on the healing of ischemic colon anastomosis was investigated. Methods: Forty eight maleWistar Albino rats were divided into four equal groups (Sham-S, Sham-I, DXP, Q10). Following full layer colon resection, single layer colon anastomosis, without creating ischemia, was performed on the Sham-S group. The same experimental model was performed on remaining groups after ischemia was created. Intraperitoneal dexpanthenol and CoQ10 was administered to the DXP and Q10 groups once a day for three days. Ten days later, all colon anastomoses were investigated histopathologically and biochemically, as well as their burst pressure values, in all sacrificed rats. Results: The highest burst pressure value was observed in the Sham-S group, decreasing from high to low in the DXP, Q10, and Sham-I groups, respectively (p = 0.008). Furthermore, tissue hydroxyproline (p = 0.001) level values were significantly different among the groups. Additionally, histopathological analysis revealed a significant difference among groups regarding reepithelization (p = 0.027) and polymorphonuclear leukocyte density (p = 0.022). Conclusions: This preliminary study has shown that ischemia-reperfusion injury may impair the healing of colon anastomosis and it has been concluded that dexpanthenol and CoQ10 may have positive effects on the healing of ischemic colon anastomosis in rat, although re-epithelization may be adversely affected using CoQ10.
dc.identifier.citationPEHLİVANLI F., AYDIN O., KARACA G., AYDIN G., DEVRİM T., BULUT H., BAKAR B., DAPHAN Ç. E. , -Healing of Ischemic Colon Anastomosis in Rats Could Be Provided by Administering Dexpanthenol or Coenzyme Q10-, JOURNAL OF CLINICAL MEDICINE, cilt.7, 2018
dc.identifier.doi10.3390/jcm7070161
dc.identifier.pubmed29941836
dc.identifier.urihttp://hdl.handle.net/20.500.12645/25510
dc.identifier.wosWOS:000440213800005
dc.titleHealing of Ischemic Colon Anastomosis in Rats Could Be Provided by Administering Dexpanthenol or Coenzyme Q10
dc.typeArticle
dspace.entity.typePublication
local.avesis.id30db78df-d9ff-461d-8efa-d25fc8c47f90
local.publication.isinternational1
relation.isAuthorOfPublicationc60929f9-74b9-495b-9c3e-282e1a8c4aec
relation.isAuthorOfPublication.latestForDiscoveryc60929f9-74b9-495b-9c3e-282e1a8c4aec
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