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Potential role of p38-mitogene-activated protein kinase and nuclear factor-kappa B expression in testicular dysfunction associated with varicocele: an experimental study

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dc.contributor.authorSimsek, A.
dc.contributor.authorOzbek, E.
dc.contributor.authorİLBEY, YUSUF ÖZLEM
dc.contributor.authorCekmen, M.
dc.contributor.authorSomay, A.
dc.contributor.authorTasci, A. I.
dc.contributor.institutionauthorİLBEY, YUSUF ÖZLEM
dc.date.accessioned2022-01-27T20:59:31Z
dc.date.available2022-01-27T20:59:31Z
dc.date.issued2012-05-01T00:00:00Z
dc.description.abstractThe aim of this study was to investigate p38-mitogene-activated protein kinase (p38-MAPK), nuclear factor-kappa B (p65-NF-kB) and inducible nitric oxide synthase (iNOS) expression in an experimental model of varicocele in the rat testis. Male Wistar albino rats (n = 18) were divided into three equal groups: control group, sham operated group and left varicocele-induced group. Malondialdehyde (MDA), nitric oxide (NO) and reduced glutathione (GSH) levels were biochemically assessed, and the p38-MAPK and NF-kB activity, and iNOS expression were immunohistochemically studied in the right and left testicles of rats from each group. The GSH levels were significantly decreased, whereas the level of MDA and NO was significantly increased in the testicular tissues of rats in varicocele group compared with those of the control and sham groups. There was a marked staining for iNOS, p38-MAPK and p65-NF-kB expression in rats of varicocele group compared with the sham group. There was no positive staining in rats of control group. There were significant differences in biochemical, histological and immunohistochemical studies, but no significant differences were noted between other groups. p38-MAPK and p65-NF-kB activation, and iNOS expression have a significant role in varicocele-induced testicular dysfunction.
dc.identifier.citationSimsek A., Ozbek E., İLBEY Y. Ö. , Cekmen M., Somay A., Tasci A. I. , -Potential role of p38-mitogene-activated protein kinase and nuclear factor-kappa B expression in testicular dysfunction associated with varicocele: an experimental study-, ANDROLOGIA, cilt.44, ss.94-101, 2012
dc.identifier.doi10.1111/j.1439-0272.2010.01145.x
dc.identifier.pubmed21671977
dc.identifier.scopus84861482745
dc.identifier.urihttp://hdl.handle.net/20.500.12645/30299
dc.identifier.wosWOS:000304439300012
dc.titlePotential role of p38-mitogene-activated protein kinase and nuclear factor-kappa B expression in testicular dysfunction associated with varicocele: an experimental study
dc.typeArticle
dspace.entity.typePublication
local.avesis.id26d775af-0d19-4b8a-9ec8-5db6749e5a8a
local.publication.isinternational1
relation.isAuthorOfPublicatione166fdca-de94-48b0-a771-14053e70c6ca
relation.isAuthorOfPublication.latestForDiscoverye166fdca-de94-48b0-a771-14053e70c6ca
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