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Cardiac Autonomic Functions in Obese Children

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dc.contributor.authorTascilar, Mehmet Emre
dc.contributor.authorYokusoglu, Mehmet
dc.contributor.authorBoyraz, Mehmet
dc.contributor.authorBaysan, Oben
dc.contributor.authorKoz, Cem
dc.contributor.authorDundaroz, Rusen
dc.contributor.institutionauthorİŞCAN, AKIN
dc.date.accessioned2020-10-22T18:32:39Z
dc.date.available2020-10-22T18:32:39Z
dc.date.issued2011-06-01T00:00:00Z
dc.description.abstractObjective: The autonomic nervous system is assumed to have a role in the pathophysiology of obesity. In this study, we evaluated the autonomic system by measuring heart rate variability (HRV) in obese children. Methods: Thirty-two obese and 30 healthy children (mean ages: 11.6 +/- 2.0 years and 11.0 +/- 2.9 years, respectively) were enrolled in the study. Obesity was defined as a body mass index higher than 97th percentile for age- and gender-specific reference values. All participants were free of any disease and none of them was receiving any medication. Twenty-four-hour ambulatory electrocardiographic recordings were obtained and the time-domain and frequency-domain indices of HRV were analyzed. The study group was evaluated with respect to insulin resistance by HOMA-IR values. Results: A significant decrease in calculated HRV variables was observed in obese children as compared to controls. The HRV alteration was found in both time-domain and frequency-domain parameters. The subgroup analysis of the study group revealed a significant decrease in all investigated HRV parameters in the insulin-resistant obese children compared to the non-insulin-resistant obese ones. Conclusions: Our results indicate that HRV is decreased in obese children, which implies parasympathetic withdrawal and sympathetic predominance. A marked decrease in HRV was observed in insulin-resistant obese children compared to their non-insulin-resistant counterparts. We propose that autonomic imbalance pertaining especially to insulin resistance may be involved in the pathogenesis of obesity in pediatric patients
dc.identifier.citationTascilar M. E. , Yokusoglu M., Boyraz M., Baysan O., Koz C., Dundaroz R., -Cardiac Autonomic Functions in Obese Children-, JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY, cilt.3, ss.60-64, 2011
dc.identifier.doi10.4274/jcrpe.v3i2.13
dc.identifier.pubmed
dc.identifier.scopus79959252361
dc.identifier.urihttp://hdl.handle.net/20.500.12645/24121
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119442/
dc.identifier.wosWOS:000497376200004
dc.subjectCardiac Autonomic Functions
dc.titleCardiac Autonomic Functions in Obese Children
dc.typeArticle
dspace.entity.typePublication
local.avesis.id879f0a43-fd59-420e-bf45-cf74f77c69b8
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isAuthorOfPublication12538a20-d5a6-4246-ab37-58afe7bbae72
relation.isAuthorOfPublication.latestForDiscovery12538a20-d5a6-4246-ab37-58afe7bbae72
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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