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Clinical evaluation of biological rhythm domains in patients with major depression

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dc.contributor.authorOzcelik, Mine
dc.contributor.authorSahbaz, Cigdem
dc.contributor.institutionauthorŞAHBAZ, ÇIĞDEM DILEK
dc.date.accessioned2020-10-22T15:55:30Z
dc.date.available2020-10-22T15:55:30Z
dc.date.issued2020-05-01T00:00:00Z
dc.description.abstractObjective: Sleep, physical activity, and social domains of biological rhythm disruptions may have specific effects on the symptom cluster and severity of depression. However, there is a lack of structured clinical evaluation to specify the domains of biological rhythms in patients with depression. Methods: Ninety drug-naïve subjects with depression and 91 matched healthy controls were recruited for the study. The severity of depression was examined with the Hamilton Rating Scale for Depression (HRSD), while biological rhythm was evaluated using the Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN). Results: Patients with depression showed significantly greater biological rhythm disturbances than healthy controls in all domains of BRIAN (sleep, activity, social, and eating). BRIAN-Total correlated positively with HRSD-Total and HRSD-Total without sleep cluster. The sleep and activity domains correlated significantly with HRSD-Total score. Additionally, the sleep, activity, and social domains correlated significantly with HRSD-Total without the sleep cluster score. Regression analysis revealed the activity (β = 0.476, t = 5.07, p<0.001) and sleep (β = 0.209, t = 2.056, p = 0.043) domains may predict HRSD-Total score.
dc.identifier.citationOzcelik M., Sahbaz C., -Clinical evaluation of biological rhythm domains in patients with major depression-, BRAZILIAN JOURNAL OF PSYCHIATRY, cilt.42, ss.258-263, 2020
dc.identifier.doi10.1590/1516-4446-2019-0570
dc.identifier.pubmed32022159
dc.identifier.scopus85085961898
dc.identifier.urihttp://hdl.handle.net/20.500.12645/23661
dc.identifier.urihttps://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462020005002202&lng=en&nrm=iso&tlng=en
dc.identifier.wosWOS:000536747800009
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDepression
dc.subjectBRIAN
dc.subjectBiological rhythm
dc.subjectPhysical activity
dc.titleClinical evaluation of biological rhythm domains in patients with major depression
dc.typeArticle
dspace.entity.typePublication
local.avesis.id4c519141-5c30-4364-812d-3111c0f30b97
local.publication.isinternational1
relation.isAuthorOfPublication5c311165-fcb8-4dfa-acec-7b954de29bfc
relation.isAuthorOfPublication.latestForDiscovery5c311165-fcb8-4dfa-acec-7b954de29bfc
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