Publication:
Protective effects of silymarin against isotretinoin induced liver and kidney injury in mice

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dc.contributor.authorKumas, MELTEM
dc.contributor.authorEsrefoglu, MUKADDES
dc.contributor.authorGuler, ERAY METİN
dc.contributor.institutionauthorKUMAŞ, MELTEM
dc.contributor.institutionauthorEŞREFOĞLU, MUKADDES
dc.contributor.institutionauthorGÜLER, ERAY METİN
dc.date.accessioned2019-10-05T14:27:20Z
dc.date.available2019-10-05T14:27:20Z
dc.date.issued2018-03-01
dc.description.abstractIsotretinoin (ISR), the common therapeuticagent for acne vulgaris, when used long term, leads to various side effects viz., oxidative toxicity, renal and hepatic dysfunction, depression, congenital abnormalities, aortic art defects, microcephaly, etc. Here, we explored the effects of silymarin (SLY), a flavonolignan from the seeds of the milk thistle Silybum marianum (L.) which has potential to protect the liver against chemical and environmental toxins and increase proliferation rate of tubule cells, against ISR induced liver and kidney injury. Thirty-two male Balb/c mice (3 months of age) were divided into four groups: control, isotretinoin (ISR, 40 mg/kg/day), silymarin (SLY, 200 mg/kg/day), and ISR+SLY group. We investigated liver and kidney injury by histopathological scoring system, and apoptotic cells labelled by TUNEL method. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were measured in serum samples biochemically. ALT and AST levels were increased in ISR group (P = 0.025, P = 0.003, respectively). SLY decreased those levels in ISR+SLY group (P = 0.002, P = 0.013, respectively). Liver tissues of ISR group showed interstitial edema and necrosis, alteration in shape and size of nuclei, mononuclear and kuppfer cell infiltration. Kidney tissues of ISR group showed tubular degeneration, necrosis, glomerular collapse, mononuclear cell infiltration, and hemorrhage. SLY improved those histopathological changes and suppressed apoptotic cell death. We suggest that silymarin might be beneficial to some extent by preventing the side effects induced by chronic ISR therapy in patients with acne vulgaris.
dc.identifier10.5262/tndt.2013.1001.10
dc.identifier.citationKumas M., Esrefoglu M., Guler E. M. , -Protective effects of silymarin against isotretinoin induced liver and kidney injury in mice-, INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY, cilt.56, ss.158-163, 2018
dc.identifier.urihttps://hdl.handle.net/20.500.12645/3933
dc.language.isoen
dc.titleProtective effects of silymarin against isotretinoin induced liver and kidney injury in mice
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameTurkish Nephrology, Dialysis and Transplantation Journal
local.avesis.id5f9d8e22-f51e-4847-8ec3-3a416b29183e
local.avesis.response3803
local.org.facultyTıp Fakültesi
local.publication.goal02 - Açlığa Son
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relation.isAuthorOfPublicationd0c7c343-3b7d-47ef-a2a7-5169234110eb
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relation.isAuthorOfPublication.latestForDiscovery68927a51-77a5-4d08-8370-23b470160061
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relation.isGoalOfPublication.latestForDiscovery5246edf8-60d4-4a7b-9a27-c73e4a636141
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