Publication:
The Effects of Transcranial Focused Ultrasound Stimulation of Nucleus Accumbens on Neuronal Gene Expression and Brain Tissue in High Alcohol-Preferring Rats

dc.contributor.authorDeveci E.
dc.contributor.authorAkbaş F.
dc.contributor.authorErgun A. Ş.
dc.contributor.authorKurtulmuş A.
dc.contributor.authorKoçak A. B.
dc.contributor.authorBoyraz R. K.
dc.contributor.authorTok O. E.
dc.contributor.authorAydın M. Ş.
dc.contributor.authorKılıç Ö.
dc.contributor.authorBozkurt A.
dc.contributor.authoret al.
dc.contributor.institutionauthorAKBAŞ, FAHRİ
dc.contributor.institutionauthorKILIÇ, ÖZGE
dc.contributor.institutionauthorEŞREFOĞLU, MUKADDES
dc.contributor.institutionauthorKOÇYİĞİT, ABDÜRRAHİM
dc.contributor.institutionauthorKIRPINAR, İSMET
dc.date.accessioned2023-01-08T21:49:01Z
dc.date.available2023-01-08T21:49:01Z
dc.date.issued2022-11-01
dc.description.abstractWe investigated the effect of low-intensity focused ultrasound (LIFU) on gene expression related to alcohol dependence and histological effects on brain tissue. We also aimed at determining the miRNA-mRNA relationship and their pathways in alcohol dependence-induced expression changes after focused ultrasound therapy. We designed a case-control study for 100 days of observation to investigate differences in gene expression in the short-term stimulation group (STS) and long-term stimulation group (LTS) compared with the control sham group (SG). The study was performed in our Experimental Research Laboratory. 24 male high alcohol-preferring rats 63 to 79 days old, weighing 270 to 300 g, were included in the experiment. LTS received 50-day LIFU and STS received 10-day LIFU and 40-day sham stimulation, while the SG received 50-day sham stimulation. In miRNA expression analysis, it was found that LIFU caused gene expression differences in NAc. Significant differences were found between the groups for gene expression. Compared to the SG, the expression of 454 genes in the NAc region was changed in the STS while the expression of 382 genes was changed in the LTS. In the LTS, the expression of 32 genes was changed in total compared to STS. Our data suggest that LIFU targeted on NAc may assist in the treatment of alcohol dependence, especially in the long term possibly through altering gene expression. Our immunohistochemical studies verified that LIFU does not cause any tissue damage. These findings may lead to new studies in investigating the efficacy of LIFU for the treatment of alcohol dependence and also for other psychiatric disorders.
dc.identifier.citationDeveci E., Akbaş F., Ergun A. Ş., Kurtulmuş A., Koçak A. B., Boyraz R. K., Tok O. E., Aydın M. Ş., Kılıç Ö., Bozkurt A., et al., "The Effects of Transcranial Focused Ultrasound Stimulation of Nucleus Accumbens on Neuronal Gene Expression and Brain Tissue in High Alcohol-Preferring Rats", MOLECULAR NEUROBIOLOGY, 2022
dc.identifier.doi10.1007/s12035-022-03130-9
dc.identifier.issn0893-7648
dc.identifier.pubmed36417101
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85142444054&origin=inward
dc.identifier.urihttps://hdl.handle.net/20.500.12645/34603
dc.relation.ispartofMOLECULAR NEUROBIOLOGY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectLife Sciences
dc.subjectNatural Sciences
dc.subjectSİNİR BİLİMİ
dc.subjectSinirbilim ve Davranış
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectNEUROSCIENCES
dc.subjectNEUROSCIENCE & BEHAVIOR
dc.subjectLife Sciences (LIFE)
dc.subjectDuyusal Sistemler
dc.subjectGelişimsel Sinirbilim
dc.subjectBilişsel Sinirbilim
dc.subjectHücresel ve Moleküler Sinirbilim
dc.subjectSinirbilim (çeşitli)
dc.subjectGenel Sinirbilim
dc.subjectİnsan Bilgisayar Etkileşimi
dc.subjectFizik Bilimleri
dc.subjectSensory Systems
dc.subjectDevelopmental Neuroscience
dc.subjectCognitive Neuroscience
dc.subjectCellular and Molecular Neuroscience
dc.subjectNeuroscience (miscellaneous)
dc.subjectGeneral Neuroscience
dc.subjectHuman-Computer Interaction
dc.subjectPhysical Sciences
dc.subjectLow-intensity focused ultrasound (LIFU)
dc.subjectAlcohol dependency
dc.subjectNucleus accumbens
dc.subjectmiRNA
dc.subjectNeuromodulation
dc.subjectFRONTAL-CORTEX
dc.subjectMICRORNA
dc.subjectETHANOL
dc.subjectADDICTION
dc.subjectCELLS
dc.subjectNEUROMODULATION
dc.subjectDYSREGULATION
dc.subjectACTIVATION
dc.subjectHISTORY
dc.subjectDISEASE
dc.titleThe Effects of Transcranial Focused Ultrasound Stimulation of Nucleus Accumbens on Neuronal Gene Expression and Brain Tissue in High Alcohol-Preferring Rats
dc.typearticle
dspace.entity.typePublication
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