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Oxidative Stress and Spontaneous Reperfusion of Infarct-Related Artery in Patients With ST-Segment Elevation Myocardial Infarction

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dc.contributor.authorBorekci, Abdurrezzak
dc.contributor.authorGur, Mustafa
dc.contributor.authorTURKOGLU, Caner
dc.contributor.authorSelek, Sahbettin
dc.contributor.authorBAYKAN, Ahmet Oytun
dc.contributor.authorSEKER, Taner
dc.contributor.authorHARBALIOGLU, Hazar
dc.contributor.authorOZALTUN, Betuel
dc.contributor.authorMAKCA, Ilyas
dc.contributor.authorAksoy, Nurten
dc.contributor.authorGOZUKARA, Yavuz
dc.contributor.authorCAYLI, Murat
dc.contributor.institutionauthorSELEK, ŞAHABETTİN
dc.date.accessioned2019-10-05T14:35:23Z
dc.date.available2019-10-05T14:35:23Z
dc.date.issued2016-03-01
dc.description.abstractIn the pathogenesis of atherosclerosis, oxidative stress plays a major role in plaque instability, rupture, and erosion, which subsequently leads to thrombus formation and causes total infarct-related artery (IRA) occlusion. We investigated the relationship between spontaneous reperfusion (SR) of IRA and oxidative stress in patients with anterior ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention. A total of 341 consecutive patients with anterior STEMI were prospectively included in the present study. Patients were divided into 2 groups according to their thrombolysis in myocardial infarction (TIMI) flow grade: SR group (66 patients, TIMI flow 3) and non-SR group (275 patients, TIMI flow 0-2). On multivariate logistic regression analysis, oxidative stress index ( = 0.868, 95% confidence interval [CI] = 0.806-0.934, P < .001), neutrophil to lymphocyte ratio, uric acid, mean platelet volume, Killip 2 to 4 class, and initial SYNTAX score were independently associated with SR. Oxidative stress as well as inflammation may play a pivotal role in the pathogenesis of SR in patients with STEMI.
dc.identifier
dc.identifier.citationBorekci A., Gur M., TURKOGLU C., Selek S., BAYKAN A. O. , SEKER T., HARBALIOGLU H., OZALTUN B., MAKCA I., Aksoy N., et al., -Oxidative Stress and Spontaneous Reperfusion of Infarct-Related Artery in Patients With ST-Segment Elevation Myocardial Infarction-, CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, cilt.22, ss.171-177, 2016
dc.identifier.doi10.1177/1076029614546329
dc.identifier.pubmed25115763
dc.identifier.scopus84957616951
dc.identifier.urihttps://hdl.handle.net/20.500.12645/4217
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/25115763/
dc.identifier.wosWOS:000370068600009
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectInfarct-related artery
dc.subjectOxidative stress
dc.titleOxidative Stress and Spontaneous Reperfusion of Infarct-Related Artery in Patients With ST-Segment Elevation Myocardial Infarction
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameAtatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi
local.avesis.id66523b46-3fe9-4577-a4a2-0d1c125f16f2
local.avesis.response4087
local.publication.isinternational1
relation.isAuthorOfPublication8eb7d539-8ea4-435c-830e-8ef630342c7d
relation.isAuthorOfPublication.latestForDiscovery8eb7d539-8ea4-435c-830e-8ef630342c7d
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