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PREDICTIVE VALUE OF ELEVATED NEUTROPHIL TO LYMPHOCYTE RATIO IN PATIENTS UNDERGOING PRIMARY ANGIOPLASTY FOR STEMI

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2013-03-01T00:00:00Z

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Ergelen, Mehmet
Uyarel, Huseyin
Kul, Seref
Altay, Servet
Ayhan, Erkan
Isik, Turgay
Kemaloglu, Tuba
Gul, Mehmet
Cicek, Gokhan
Tasal, Abdurrahman

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Abstract

Background Leukocytes total count is an independent risk marker for cardiovascular events. The ratio between neutrophils and lymphocytes counts (NLR) has been investigated as a new predictor for cardiovascular risk. We hypothesized that admission NLR would be predictive of adverse outcomes after primary angioplasty for ST-segment elevation myocardial infarction (STEMI). Methods 2410 consecutive STEMI patients (mean age 56.2 ± 11.7 years, 2015 male, 395 female) undergoing primary angioplasty were retrospectively enrolled into the present study. The study population was divided into tertiles based on admission NLR values. A high NLR (n=803) was defined as a value in the third tertile (>6.97), and a low NLR (n=1607) was defined as a value in the lower two tertiles (≤6.97). The median follow-up time was 21 months. Clinical characteristics, in-hospital and long-term outcomes of primary angioplasty were analysed. Results High NLR group had significantly higher incidence of in-hospital cardiovascular mortality and advanced heart failure than low NLR group (5 % vs 1.4%, p<0.001; 17.1% vs 9.9%, p<0.001, respectively). The median follow-up time was 21 months. Long-term cardiovascular mortality and advanced heart failure rates were significantly higher in patients with high NLR. (7% vs 4.8 %, p=0.02; 11.4 % vs 7.3%, p=0.002, respectively). By multivariate logistic regression analysis; high admission NLR (>6.97) was found a powerful independent predictor of in-hospital cardiovascular mortality (odds ratio: 2.8, 95% confidence interval: 1.37–5.74, p=0.005). Conclusions These results suggest that high admission NLR level is associated with increased in-hospital and long-term cardiovascular mortality in patients with STEMI undergoing primary angioplasty.

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stemi

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Ergelen M., Uyarel H., Kul S., Altay S., Ayhan E., Isik T., Kemaloglu T., Gul M., Cicek G., Tasal A., et al., -PREDICTIVE VALUE OF ELEVATED NEUTROPHIL TO LYMPHOCYTE RATIO IN PATIENTS UNDERGOING PRIMARY ANGIOPLASTY FOR STEMI-, 62nd Annual Scientific Session of the American-College-of-Cardiology, San-Francisco, Kostarika, 9 - 11 Mart 2013, cilt.61
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