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Gamma glutamyl transferase activity is Independently associated with oxidative stress rather than SYNTAX score

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dc.contributor.authorUCAR, Hakan
dc.contributor.authorGUR, Mustafa
dc.contributor.authorGOZUKARA, Mehmet Yavuz
dc.contributor.authorKALKAN, Gulhan Yuksel
dc.contributor.authorBAYKAN, Ahmet Oytun
dc.contributor.authorTURKOGLU, Caner
dc.contributor.authorKAYPAKLI, Onur
dc.contributor.authorSEKER, Taner
dc.contributor.authorSEN, Omer
dc.contributor.authorSelek, Sahbettin
dc.contributor.authorCAYLI, Murat
dc.contributor.institutionauthorSELEK, ŞAHABETTİN
dc.date.accessioned2019-10-05T21:19:59Z
dc.date.available2019-10-05T21:19:59Z
dc.date.issued2015-01-01
dc.description.abstractBackground. Gamma glutamyl transferase (GGT) is involved in the pathophysiologic process of coronary atherosclerosis. GGT activity plays a role in the catabolism of glutathione which is known as one of the major antioxidants. However, there is a lack of research on direct examination of relevance between serum GGT activity with systemic oxidative stress. Objectives. We aimed to investigate the relationship between GGT activity with systemic oxidative stress markers and the extent and complexity of coronary artery disease (CAD) assessed with SYNTAX score in stable CAD. Methods. Measurements were obtained from 359 patients with stable CAD (Mean age = 57.7 +/- 10.1 years). The patients were divided into two groups according to the median GGT level (GGT median group > 22). Angiography was performed and SYNTAX score was calculated in all patients. Oxidative stress markers (total oxidant status [TOS], total antioxidant capacity [TAC] and oxidative stress index [OSI]) were measured in all patients. Results. While SYNTAX score and oxidative stress markers such as TOS and OSI have been increased, TAC was decreased in GGT > median group compared with GGT < median group (p < 0.05, for all). GGT activity was independently associated with diabetes (beta = 0.106, p = 0.015) and OSI (beta = 0.556, p < 0.001) in multiple linear regression analysis. However, the independent association between GGT activity and SYNTAX score was not found in present study (beta = 0.063, p = 0.238). Conclusion. In stable CAD, increased GGT activity within the normal range is associated with increased oxidative stress rather than increased extent and complexity of CAD.
dc.identifier
dc.identifier.citationUCAR H., GUR M., GOZUKARA M. Y. , KALKAN G. Y. , BAYKAN A. O. , TURKOGLU C., KAYPAKLI O., SEKER T., SEN O., Selek S., et al., -Gamma glutamyl transferase activity is Independently associated with oxidative stress rather than SYNTAX score-, SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, cilt.75, ss.7-12, 2015
dc.identifier.urihttps://hdl.handle.net/20.500.12645/7099
dc.language.isoen
dc.titleGamma glutamyl transferase activity is Independently associated with oxidative stress rather than SYNTAX score
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameERCIYES MEDICAL JOURNAL
local.avesis.idb12ce8de-e3a0-4591-9932-992cee6a0d2f
local.avesis.response6975
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
relation.isAuthorOfPublication8eb7d539-8ea4-435c-830e-8ef630342c7d
relation.isAuthorOfPublication.latestForDiscovery8eb7d539-8ea4-435c-830e-8ef630342c7d
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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