Publication:
Role of Probiotics in the Management of COVID-19: A Computational Perspective

dc.contributor.authorNguyen, Quang Vo
dc.contributor.authorChong, Li Chuin
dc.contributor.authorHor, Yan-Yan
dc.contributor.authorLew, Lee-Ching
dc.contributor.authorRather, Irfan A.
dc.contributor.authorChoi, Sy-Bing
dc.date.accessioned2022-02-08T20:59:10Z
dc.date.available2022-02-08T20:59:10Z
dc.date.issued2022-01-01T00:00:00Z
dc.description.abstractCoronavirus disease 2019 (COVID-19) was declared a pandemic at the beginning of 2020, causing millions of deaths worldwide. Millions of vaccine doses have been administered worldwide; however, outbreaks continue. Probiotics are known to restore a stable gut microbiota by regulating innate and adaptive immunity within the gut, demonstrating the possibility that they may be used to combat COVID-19 because of several pieces of evidence suggesting that COVID-19 has an adverse impact on gut microbiota dysbiosis. Thus, probiotics and their metabolites with known antiviral properties may be used as an adjunctive treatment to combat COVID-19. Several clinical trials have revealed the efficacy of probiotics and their metabolites in treating patients with SARS-CoV-2. However, its molecular mechanism has not been unraveled. The availability of abundant data resources and computational methods has significantly changed research finding molecular insights between probiotics and COVID-19. This review highlights computational approaches involving microbiome-based approaches and ensemble-driven docking approaches, as well as a case study proving the effects of probiotic metabolites on SARS-CoV-2.
dc.identifier.doi10.3390/nu14020274
dc.identifier.pubmed35057455
dc.identifier.scopus85122340606
dc.identifier.urihttp://hdl.handle.net/20.500.12645/30376
dc.identifier.wosWOS:000747746800001
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectprobiotics
dc.subjectSARS-CoV-2
dc.subjectCOVID-19
dc.subjectcomputational approach
dc.subjectgut-lung axis
dc.subjectmicrobiome
dc.subjectmolecular docking
dc.titleRole of Probiotics in the Management of COVID-19: A Computational Perspective
dc.typeArticle
dspace.entity.typePublication
local.avesis.id340880ee-6fbb-42e7-9abf-8872dc37586d
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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