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Thiosemicarbazide-Substituted Coumarins as Selective Inhibitors of the Tumor Associated Human Carbonic Anhydrases IX and XII

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dc.contributor.authorGÜMÜŞ PALABIYIK, ARZU
dc.contributor.authorBozdag, Murat
dc.contributor.authorAKDEMİR, ATİLLA
dc.contributor.authorAngeli, Andrea
dc.contributor.authorSelleri, Silvia
dc.contributor.authorCarta, Fabrizio
dc.contributor.authorSupuran, Claudiu T.
dc.contributor.institutionauthorAKDEMİR, ATİLLA
dc.date.accessioned2022-08-20T17:09:50Z
dc.date.available2022-08-20T17:09:50Z
dc.date.issued2022-07-01T00:00:00Z
dc.description.abstractA novel series of thiosemicarbazide-substituted coumarins was synthesized and the inhibitory effects against four physiologically relevant carbonic anhydrase isoforms I, II, IX and XII showed selective activities on the tumor-associated IX and XII isozymes. Molecular modeling studies on selected compounds 14a and 22a were performed. The binding modes of such compounds were determined assuming their enzymatically active structures (i.e., cinnamic acid) in the thermodynamically favored, and not previously explored, E geometry. Molecular modelling suggests multiple interactions within the enzymatic cavity and may explain the high potency and selectivity reported for the hCAs IX and XII.
dc.identifier.citationGÜMÜŞ PALABIYIK A., Bozdag M., AKDEMİR A., Angeli A., Selleri S., Carta F., Supuran C. T. , -Thiosemicarbazide-Substituted Coumarins as Selective Inhibitors of the Tumor Associated Human Carbonic Anhydrases IX and XII-, MOLECULES, cilt.27, sa.14, 2022
dc.identifier.doi10.3390/molecules27144610
dc.identifier.pubmed35889480
dc.identifier.scopus85135120502
dc.identifier.urihttp://hdl.handle.net/20.500.12645/30875
dc.identifier.wosWOS:000833159600001
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleThiosemicarbazide-Substituted Coumarins as Selective Inhibitors of the Tumor Associated Human Carbonic Anhydrases IX and XII
dc.typeArticle
dspace.entity.typePublication
local.avesis.id5224f3b7-7c93-464f-af2b-df4e117f3c01
local.publication.isinternational1
relation.isAuthorOfPublication19bc513a-c695-4e72-ba1d-83b8d6c574c8
relation.isAuthorOfPublication.latestForDiscovery19bc513a-c695-4e72-ba1d-83b8d6c574c8
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