Publication: An HPLC Method for the Determination of Moxifloxacin in Breast Milk by Fluorimetric Detection with Precolumn Derivatization
dc.contributor.author | Tekkeli, S. E. Kepekci | |
dc.contributor.author | GAZIOGLU, IŞIL | |
dc.contributor.author | KIZILTAS, M. V. | |
dc.contributor.institutionauthor | TEKKELİ, ŞERİFE EVRİM | |
dc.contributor.institutionauthor | GAZİOĞLU, IŞIL | |
dc.date.accessioned | 2019-10-05T21:17:09Z | |
dc.date.available | 2019-10-05T21:17:09Z | |
dc.date.issued | 2017-03-01 | |
dc.description.abstract | A new, sensitive, and selective high-performance liquid chromatography (HPLC) method with fluorimetric detection was developed for the determination of moxifloxacin (MOX) in human breast milk. MOX was precolumn derivatized with fluorescamine; the fluorescent derivative was separated on an RP C18 column using a mobile phase composed of acetonitrile-10 mM orthophosphoric acid by isocratic elution with flow rate of 0.5 mL min(-1). The method was based on the measurement of the derivative using fluorescence detection at 481 nm with excitation at 351 nm. The calibration curve was linear over the range of 1-40 mu g mL(-1). Limit of detection (LOD) and limit of quantitation (LOQ) were found to be 0.3 and 1 mu g mL(-1), respectively. Intra-day and interday repeatabilities were less than 3.15%. | |
dc.identifier | 10.1002/jcla.21505 | |
dc.identifier.citation | Tekkeli S. E. K. , GAZIOGLU I., KIZILTAS M. V. , -An HPLC Method for the Determination of Moxifloxacin in Breast Milk by Fluorimetric Detection with Precolumn Derivatization-, ACTA CHROMATOGRAPHICA, cilt.29, ss.57-65, 2017 | |
dc.identifier.doi | 10.1556/1326.2017.29.1.4 | |
dc.identifier.scopus | 85014672567 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12645/6969 | |
dc.identifier.uri | https://akjournals.com/view/journals/1326/29/1/article-p57.xml | |
dc.identifier.wos | WOS:000394326700005 | |
dc.language.iso | en | |
dc.title | An HPLC Method for the Determination of Moxifloxacin in Breast Milk by Fluorimetric Detection with Precolumn Derivatization | |
dc.type | Article | |
dspace.entity.type | Publication | |
local.article.journalname | JOURNAL OF CLINICAL LABORATORY ANALYSIS | |
local.avesis.id | ae0d3f0d-6351-4dab-b39e-5c161303de0c | |
local.avesis.response | 6845 | |
local.indexed.at | WOS | |
local.indexed.at | Scopus | |
local.publication.isinternational | 1 | |
relation.isAuthorOfPublication | 837d5047-762e-43db-b252-9f3d1399378f | |
relation.isAuthorOfPublication | 336380d2-70ee-496d-a002-08059f9da500 | |
relation.isAuthorOfPublication.latestForDiscovery | 336380d2-70ee-496d-a002-08059f9da500 |
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