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An HPLC Method for the Determination of Moxifloxacin in Breast Milk by Fluorimetric Detection with Precolumn Derivatization

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dc.contributor.authorTekkeli, S. E. Kepekci
dc.contributor.authorGAZIOGLU, IŞIL
dc.contributor.authorKIZILTAS, M. V.
dc.contributor.institutionauthorTEKKELİ, ŞERİFE EVRİM
dc.contributor.institutionauthorGAZİOĞLU, IŞIL
dc.date.accessioned2019-10-05T21:17:09Z
dc.date.available2019-10-05T21:17:09Z
dc.date.issued2017-03-01
dc.description.abstractA new, sensitive, and selective high-performance liquid chromatography (HPLC) method with fluorimetric detection was developed for the determination of moxifloxacin (MOX) in human breast milk. MOX was precolumn derivatized with fluorescamine; the fluorescent derivative was separated on an RP C18 column using a mobile phase composed of acetonitrile-10 mM orthophosphoric acid by isocratic elution with flow rate of 0.5 mL min(-1). The method was based on the measurement of the derivative using fluorescence detection at 481 nm with excitation at 351 nm. The calibration curve was linear over the range of 1-40 mu g mL(-1). Limit of detection (LOD) and limit of quantitation (LOQ) were found to be 0.3 and 1 mu g mL(-1), respectively. Intra-day and interday repeatabilities were less than 3.15%.
dc.identifier10.1002/jcla.21505
dc.identifier.citationTekkeli S. E. K. , GAZIOGLU I., KIZILTAS M. V. , -An HPLC Method for the Determination of Moxifloxacin in Breast Milk by Fluorimetric Detection with Precolumn Derivatization-, ACTA CHROMATOGRAPHICA, cilt.29, ss.57-65, 2017
dc.identifier.doi10.1556/1326.2017.29.1.4
dc.identifier.scopus85014672567
dc.identifier.urihttps://hdl.handle.net/20.500.12645/6969
dc.identifier.urihttps://akjournals.com/view/journals/1326/29/1/article-p57.xml
dc.identifier.wosWOS:000394326700005
dc.language.isoen
dc.titleAn HPLC Method for the Determination of Moxifloxacin in Breast Milk by Fluorimetric Detection with Precolumn Derivatization
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameJOURNAL OF CLINICAL LABORATORY ANALYSIS
local.avesis.idae0d3f0d-6351-4dab-b39e-5c161303de0c
local.avesis.response6845
local.publication.isinternational1
relation.isAuthorOfPublication837d5047-762e-43db-b252-9f3d1399378f
relation.isAuthorOfPublication336380d2-70ee-496d-a002-08059f9da500
relation.isAuthorOfPublication.latestForDiscovery336380d2-70ee-496d-a002-08059f9da500
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