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Discovery of novel isatin-based sulfonamides with potent and selective inhibition of the tumor-associated carbonic anhydrase isoforms IX and XII.

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dc.contributor.authorGÜZEL-AKDEMIR, Ö
dc.contributor.authorAkdemir, ATİLLA
dc.contributor.authorKARALı, N
dc.contributor.authorSUPURAN, CT
dc.contributor.institutionauthorAKDEMİR, ATİLLA
dc.date.accessioned2019-10-05T15:23:25Z
dc.date.available2019-10-05T15:23:25Z
dc.date.issued2015-06-21
dc.description.abstractA series of 2/3/4-[(2-oxo-1,2-dihydro-3H-indol-3-ylidene)amino]benzenesulfonamides, obtained from substituted isatins and 2-, 3- or 4-aminobenzenesulfonamide, showed low nanomolar inhibitory activity against the tumor associated carbonic anhydrase (CA, EC 4.2.1.1) isoforms IX and XII – recently validated antitumor drug targets, being much less effective as inhibitors of the off-target cytosolic isoforms CA I and II.
dc.identifier10.1016/j.cmi.2015.07.013
dc.identifier.citationGÜZEL-AKDEMIR Ö., Akdemir A., KARALı N., SUPURAN C., -Discovery of novel isatin-based sulfonamides with potent and selective inhibition of the tumor-associated carbonic anhydrase isoforms IX and XII.-, Organic & biomolecular chemistry, cilt.13, ss.6493-9, 2015
dc.identifier.doi10.1039/c5ob00688k
dc.identifier.pubmed
dc.identifier.scopus84930681208
dc.identifier.urihttps://hdl.handle.net/20.500.12645/6180
dc.identifier.urihttps://pubs.rsc.org/en/content/articlelanding/2015/OB/C5OB00688K#!divAbstract
dc.identifier.wosWOS:000355859600011
dc.language.isoen
dc.subjecttumor
dc.titleDiscovery of novel isatin-based sulfonamides with potent and selective inhibition of the tumor-associated carbonic anhydrase isoforms IX and XII.
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameCLINICAL MICROBIOLOGY AND INFECTION
local.avesis.id99856404-153c-48ab-9095-e7986dcf42bb
local.avesis.response6050
local.indexed.atPubMed
local.indexed.atWOS
local.indexed.atScopus
local.publication.isinternational1
relation.isAuthorOfPublication19bc513a-c695-4e72-ba1d-83b8d6c574c8
relation.isAuthorOfPublication.latestForDiscovery19bc513a-c695-4e72-ba1d-83b8d6c574c8

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