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Effects of boric acid-linked ampicillin on the rat intra-abdominal sepsis model

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dc.contributor.authorIdiz, Ufuk Oguz
dc.contributor.authorAysan, Erhan
dc.contributor.authorFirat, Deniz
dc.contributor.authorERCAN, ÇİLEM
dc.contributor.authorDemirci, Selami
dc.contributor.authorSahin, Fikrettin
dc.contributor.institutionauthorAYŞAN, MUSTAFA ERHAN
dc.contributor.institutionauthorERCAN, ÇİLEM
dc.date.accessioned2020-10-22T18:33:48Z
dc.date.available2020-10-22T18:33:48Z
dc.date.issued2019-03-01T00:00:00Z
dc.description.abstractThe aim of this study was to determine efficiency of a new molecule that was obtained by linking boric acid with ampicillin in treating intra-abdominal infection. Following intraperitoneal E. coli injection totwenty-one female Wistar albino rats, group 1 was administered boron-linked ampicillin, group 2 was administered only ampicillin and group 3 was injected intraperitoneally with physiological serum. IL-6, and a white blood cell analysis was performed from the blood before and on the seventh day of treatment. No statistically significant difference in blood WBC levels after treatment was found among the groups. There was no statistically significant difference in the IL-6 values of group 2 and group 3 before and after the treatment (p=0.195 and 0.193, respectively); however, the reduction in the serum IL-6 values of group 1 was statistically significant (p=0.003). Boric acid-linked ampicillin is a more effective intra-abdominal infection treatment compared with ampicillin alone.
dc.identifier.citationIdiz U. O. , Aysan E., Firat D., ERCAN Ç., Demirci S., Sahin F., -Effects of boric acid-linked ampicillin on the rat intra-abdominal sepsis model-, PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.32, ss.477-481, 2019
dc.identifier.pubmed31081755
dc.identifier.scopus85062389936
dc.identifier.urihttp://hdl.handle.net/20.500.12645/24162
dc.identifier.wosWOS:000465065000001
dc.titleEffects of boric acid-linked ampicillin on the rat intra-abdominal sepsis model
dc.typeArticle
dspace.entity.typePublication
local.avesis.id8db9dca4-e0c5-4b2a-abe4-eb6820932566
local.publication.isinternational1
relation.isAuthorOfPublication886ea820-98fa-449a-8b4b-26efeff939d8
relation.isAuthorOfPublication4b62f88a-cbba-4426-b872-f37090254c3b
relation.isAuthorOfPublication.latestForDiscovery886ea820-98fa-449a-8b4b-26efeff939d8
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