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Which Cholinesterase Inhibitor is the Safest for the Heart in Elderly Patients With Alzheimer-s Disease?

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dc.contributor.authorISIK, Ahmet Turan
dc.contributor.authorBOZOGLU, Ergun
dc.contributor.authorYAY, Adnan
dc.contributor.authorSoysal, PINAR
dc.contributor.authorATESKAN, Umit
dc.contributor.institutionauthorSOYSAL, PINAR
dc.date.accessioned2020-10-29T20:40:51Z
dc.date.available2020-10-29T20:40:51Z
dc.date.issued2012-05-01T00:00:00Z
dc.description.abstractObjective: Cholinesterase inhibitors (ChEIs) are widely used for the treatment of Alzheimer-s disease (AD); however, their cholinergic side effects on the cardiovascular system are still unclear. In this study, we aimed to examine the side effects caused by donepezil, rivastigmine, and galantamine on cardiac rhythm and postural blood pressure changes in elderly patients with AD. Methods: Of 204 consecutive elderly patients who were newly diagnosed with AD, 162 were enrolled and underwent comprehensive geriatric assessments. The electrocardiographs (ECGs) and blood pressures were recorded at the baseline and 4 weeks after the dose of 10 mg/d of donepezil, 10 cm2/d of rivastigmine, and 24 mg/d of galantamine. Results: There were no changes relative to the baseline in any of the ECG parameters or arterial blood pressure with any of the administered ChEIs. Conclusion: It was demonstrated that none of the 3 ChEIs were associated with increased negative chronotropic, arrhythmogenic, and hypotensive effects for the elderly patients with AD.
dc.identifier.citationISIK A. T. , BOZOGLU E., YAY A., Soysal P., ATESKAN U., -Which Cholinesterase Inhibitor is the Safest for the Heart in Elderly Patients With Alzheimer-s Disease?-, AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS, cilt.27, ss.171-174, 2012
dc.identifier.doi10.1177/1533317512442999
dc.identifier.pubmed22573283
dc.identifier.scopus84865412244
dc.identifier.urihttp://hdl.handle.net/20.500.12645/26151
dc.identifier.wosWOS:000303831300005
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleWhich Cholinesterase Inhibitor is the Safest for the Heart in Elderly Patients With Alzheimer-s Disease?
dc.typeArticle
dspace.entity.typePublication
local.avesis.id7669111a-9a9b-4070-b523-748b4822deb0
local.publication.isinternational1
relation.isAuthorOfPublication0e36986e-d71d-4579-a395-877af097ade5
relation.isAuthorOfPublication.latestForDiscovery0e36986e-d71d-4579-a395-877af097ade5
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