Publication: Pasif sigara içen çocuklarda katalaz, tiyol ve myeloperoksidaz düzeylerinin değerlendirilmesi / Evaluation of katalaz, thiol and myeloperoxideas levels in children with passive cigarette
Passive smoking threatens human health at every stage of life, but it is more harmful to children in the first stages of life. 700 million children around the world are experiencing the harmful effects of passive smoking. In the United States, 15 million children are found to be passive smokers. Passive smoking is also a very important health problem in Turkey. Cigarette smoke contains more than 4000 parts of known and 100.000 parts of unknown components. Cigarette smoke contains oxidants and gases with prooxidant properties, which are emitted in condensed tar particles. Evidence suggests that passive smoking increases free radical production, leads to the depletion of antioxidants and increases oxidative stress. Free radicals found in cigarette smoke can harm all tissues and cellular structures in our bodies. Oxidative stress caused by the increase of free radicals can affect the antioxidant levels in our bodies. In our study, we compared catalase, thiol, and myeloperoxidase serum levels of natural antioxidants in children with passive cigarette smoking to a healthy control group that was not exposed to passive smoking. Among the 4-17 year olds, 24 girls and 17 boys with passive smoking and 18 healthy girls and 12 healthy boys were used in this study. Myeloperoxidase levels were significant higher in passive cigarette smoking group compared with non-passive smokers (p = 0,039). Catalase and thiol levels were not significantly different between the patient and control group when we compared according to demographic characteristics and laboratory findings ( p = 0,926, p=0,629). In conclusion, it was thought that passive cigarette smoking had an effect on the antioxidant system in our body and that the increase of myeloperoxidase enzyme level, which plays an important role in body defense, due to passive smoking could be a protection mechanism for body defense.