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Cytotoxic Activities of Several Geranyl-Substituted Flavanones

dc.contributor.authorSMEJKAL, Karel
dc.contributor.authorSVACINOVA, Jana
dc.contributor.authorSLAPETOVA, Tereza
dc.contributor.authorSCHNEIDEROVA, Kristyna
dc.contributor.authorDALL'ACQUA, Stefano
dc.contributor.authorINNOCENTI, Gabbriella
dc.contributor.authorZAVALOVA, Veronika
dc.contributor.authorKOLLAR, Peter
dc.contributor.authorCHUDIK, Stanislav
dc.contributor.authorMAREK, Radek
dc.contributor.authorJULINEK, Ondrej
dc.contributor.authorURBANOVA, Marie
dc.contributor.authorKartal, MURAT
dc.contributor.authorCSOELLEI, Marek
dc.contributor.authorDOLEZAL, Karel
dc.contributor.institutionauthorKARTAL, MURAT
dc.date.accessioned2020-10-29T22:25:08Z
dc.date.available2020-10-29T22:25:08Z
dc.date.issued2010-04-01T00:00:00Z
dc.description.abstractNine geranylated flavanones isolated from the fruits of Paulownia tomentosa (4-12) and two from the roots of Moms alba (13 and 14) were examined for cytotoxicity to selected human cancer cell lines and normal human fibroblasts. Cytotoxicity was determined in vitro using a calcein AM cytotoxicity assay. Cytotoxicity for the TIP-1 monocytic leukemia cell line was tested using erythrosin B cell staining. The geranylated compounds tested were compared with the known simple flavanone standards taxifolin (1), naringenin (2), and hesperetin (3) and with the standard anticancer drugs olomoucine II, diaziquone, and oxaliplatin and the antineoplastic compound camptothecin, and showed different levels of cytotoxicity. The effects of structural changes on cytotoxic activity, including gentnyl substitution of the flavanone skeleton and the oxidation pattern of ring B of the flavanones, are discussed.
dc.identifier.citationSMEJKAL K., SVACINOVA J., SLAPETOVA T., SCHNEIDEROVA K., DALL-ACQUA S., INNOCENTI G., ZAVALOVA V., KOLLAR P., CHUDIK S., MAREK R., et al., -Cytotoxic Activities of Several Geranyl-Substituted Flavanones-, JOURNAL OF NATURAL PRODUCTS, cilt.73, ss.568-572, 2010
dc.identifier.doi10.1021/np900681y
dc.identifier.scopus77951539852
dc.identifier.urihttp://hdl.handle.net/20.500.12645/26608
dc.identifier.wosWOS:000276950000011
dc.titleCytotoxic Activities of Several Geranyl-Substituted Flavanones
dc.typeArticle
dspace.entity.typePublication
local.avesis.idb166a95b-34fd-4c47-adaa-986fec3b8bc5
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
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relation.isAuthorOfPublication.latestForDiscoveryb30ec030-5f34-4c8b-814e-a7131d524a0a
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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