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Coagulation parameters in inflammatory bowel disease

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dc.contributor.authorDOLAPCIOGLU, Can
dc.contributor.authorSOYLU, Aliye
dc.contributor.authorKENDIR, Tulin
dc.contributor.authorInce, ALİ TÜZÜN
dc.contributor.authorDOLAPCIOGLU, Hatice
dc.contributor.authorPurisa, Sevim
dc.contributor.authorBOLUKBAS, Cengiz
dc.contributor.authorSOKMEN, Haci Mehmet
dc.contributor.authorDALAY, Remzi
dc.contributor.authorOVUNC, Oya
dc.contributor.institutionauthorİNCE, ALİ TÜZÜN
dc.date.accessioned2019-10-05T13:48:31Z
dc.date.available2019-10-05T13:48:31Z
dc.date.issued2014-01-01
dc.description.abstractThromboembolic events represent a major cause of morbidity and mortality in patients with inflammatory bowel disease and they may occur both at the gastrointestinal tract and at extraintestinal sites. This study aimed to examine the alterations in coagulation parameters involved at different steps of hemostasis in patients with Crohn’s disease and ulcerative colitis, in comparison with healthy individuals. Fifty-one patients with inflammatory bowel disease and 26 healthy controls were included in this study. Plasma levels of PT, APTT, AT III, plasminogen, fibrinogen, D-dimer, factor V, factor VIII, protein C, protein S, and APCR were measured and factor V Leiden mutation was examined in both patients and controls. Two patients with ulcerative colitis had a history of previous thromboembolic event. Inflammatory bowel disease was associated with significantly higher levels of fibrinogen, PT, factor V, factor VIII, plasminogen and thrombocyte. Protein S, fibrinogen, plasminogen and thrombocyte levels were associated with disease activity, depending on the type of the disease (Crohn’s disease or ulcerative colitis). The coagulation abnormalities detected in this study seems to be a secondary phenomena resulting from the disease process, which is more likely to be associated with a multitude of factors rather than a single abnormalityen
dc.identifier10.1097/scs.0000000000004256
dc.identifier.citationDOLAPCIOGLU C., SOYLU A., KENDIR T., Ince A. T. , DOLAPCIOGLU H., Purisa S., BOLUKBAS C., SOKMEN H. M. , DALAY R., OVUNC O., -Coagulation parameters in inflammatory bowel disease-, INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, cilt.7, ss.1442-1448, 2014
dc.identifier.doi10.1016/j.thromres.2008.04.004
dc.identifier.pubmed24995109
dc.identifier.scopus58949099542
dc.identifier.urihttps://hdl.handle.net/20.500.12645/3051
dc.identifier.wosWOS:000341254800036
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleCoagulation parameters in inflammatory bowel disease
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameJOURNAL OF CRANIOFACIAL SURGERY
local.avesis.id4a038c91-7a18-49e0-99e4-402e47cd7d76
local.avesis.response2921
local.publication.isinternational1
relation.isAuthorOfPublication6daa6ab7-ee45-4f50-9e71-e831046b6462
relation.isAuthorOfPublication.latestForDiscovery6daa6ab7-ee45-4f50-9e71-e831046b6462
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