Publication:
The Effects of Potassium Channels in Human Internal Mammary Artery

dc.contributor.authorAfsar, Selim
dc.contributor.authorHemsinli, Dogus
dc.contributor.authorOzyazgan, Sibel
dc.contributor.authorAkkan, Ahmet Gökhan
dc.contributor.authorArslan, Caner
dc.contributor.institutionauthorAKKAN, AHMET GÖKHAN
dc.date.accessioned2021-01-21T20:59:31Z
dc.date.available2021-01-21T20:59:31Z
dc.date.issued2016-01-01T00:00:00Z
dc.description.abstractBackground: Structural and functional changes in potassium channels of vascular smooth muscle cells may contribute to the development of diseases such as hypertension. We aim to investigate the vascular effects of potassium channel openers and blockers in human internal mammary artery (HIMA). Methods: Remaining segments of HIMA from 18 consecutive patients undergoing coronary artery bypass surgery were obtained to examine the vascular effects of various potassium channel openers (staurosporine, hydrochlorothiazide and cromakalim) and potassium channel blockers (4-aminopyridin [4-AP], charybdotoxin [CTX] and glibenclamide [GLBC]). Results: Noradrenaline (NA)-induced maximal contractions were inhibited by all 3 K+-channel blockers but only fully inhibited by 4-AP (95.6%). Only NA-induced contractions were reversed by CTX. Only K+-induced maximal contractions were significantly inhibited by 4-AP (95.6%, p < 0.05). Only acetylcholine-induced relaxation was fully inhibited by CTX. Only sodium nitroprusside-induced relaxations in potassium chloride-precontracted strips could be reversed by GLBC. Conclusions: Drugs affecting potassium channels may be useful in the treatment of hypertension and management of perioperative vasospasm during the coronary artery bypass surgery. (C) 2015 S. Karger AG, Basel
dc.identifier.citationAfsar S., Hemsinli D., Ozyazgan S., Akkan A. G. , Arslan C., -The Effects of Potassium Channels in Human Internal Mammary Artery-, PHARMACOLOGY, cilt.97, ss.72-77, 2016
dc.identifier.doi10.1159/000442528
dc.identifier.scopus84955216207
dc.identifier.urihttp://hdl.handle.net/20.500.12645/28095
dc.identifier.wosWOS:000368188300011
dc.titleThe Effects of Potassium Channels in Human Internal Mammary Artery
dc.typeArticle
dspace.entity.typePublication
local.avesis.ida18efe88-45aa-4f1c-a8d6-a53c54a95b62
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isAuthorOfPublication3d01b102-caf1-4fba-a467-f358f2f6d3c7
relation.isAuthorOfPublication.latestForDiscovery3d01b102-caf1-4fba-a467-f358f2f6d3c7
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c

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