Publication:
Comparison of Cytokine Hemadsorption as an Immunomodulator Therapy in COVID-19 Patients with and without Bacterial Sepsis

dc.contributor.authorKoc S.
dc.contributor.authorHanikoglu F.
dc.contributor.authorDokur M.
dc.contributor.authorPolat Y.
dc.contributor.authorCelebi S.
dc.contributor.authorKoc S. G.
dc.contributor.authorKupeli I.
dc.contributor.authorUYSAL H.
dc.contributor.institutionauthorUYSAL, HARUN
dc.date.accessioned2023-01-08T22:58:40Z
dc.date.available2023-01-08T22:58:40Z
dc.date.issued2022-10-01
dc.description.abstract© 2022 Verlag Klinisches Labor GmbH. All rights reserved.Background: In this retrospective study, we aimed to compare the laboratory and clinical results of cytokine hemadsorption as an immunomodulation therapy in COVID-19 ICU patients with or without sepsis. Methods: The levels of PCT, CRP, and ferritin were determined as indicators of infection/sepsis; the levels of interleukins (IL-6, IL-8 and IL-10, and TNF-α) were determined as indicators of cytokine storm were compared. APACHE score, SOFA score, and mortality rates were compared for the progression of the disease in 23 COVID-19 patients. Results: The therapy was generally successful in reducing the levels of IL-6, IL-8, IL-10, and TNF-α but the levels measured after the procedure did not differ among the patients with or without sepsis, suggesting that the presence of sepsis did not affect the efficacy and function of the cytokine hemadsorption procedure in COVID-19 patients. All parameters were reduced after the procedure except the levels of PCT and ferritin and mortality rates of patients diagnosed with sepsis. The level of PCT was significantly higher in these patients compared with the patients without sepsis while the ferritin and mortality did not show any significant difference between the two groups, suggesting that the cytokine hemadsorption may be safe in the treatment of critical COVID-19 patients. Conclusions: As a result, the progression of sepsis in COVID-19 may be avoided with cytokine hemadsorption applied as an immunomodulator therapy. However, this therapy should be further explored and validated prior to its introduction to everyday clinical practice when the epidemic conditions end.
dc.identifier.citationKoc S., Hanikoglu F., Dokur M., Polat Y., Celebi S., Koc S. G., Kupeli I., UYSAL H., "Comparison of Cytokine Hemadsorption as an Immunomodulator Therapy in COVID-19 Patients with and without Bacterial Sepsis", Clinical Laboratory, cilt.68, sa.10, ss.2104-2111, 2022
dc.identifier.doi10.7754/clin.lab.2022.211249
dc.identifier.endpage2111
dc.identifier.issn1433-6510
dc.identifier.issue10
dc.identifier.startpage2104
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85140271212&origin=inward
dc.identifier.urihttps://hdl.handle.net/20.500.12645/34918
dc.identifier.volume68
dc.relation.ispartofClinical Laboratory
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectTemel Bilimler
dc.subjectLife Sciences
dc.subjectMolecular Biology and Genetics
dc.subjectCytogenetic
dc.subjectNatural Sciences
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.subjectLife Sciences (LIFE)
dc.subjectMOLECULAR BIOLOGY & GENETICS
dc.subjectBIOCHEMISTRY & MOLECULAR BIOLOGY
dc.subjectGenel Biyokimya, Genetik ve Moleküler Biyoloji
dc.subjectGeneral Biochemistry, Genetics and Molecular Biology
dc.subjectCOVID-19
dc.subjectcytokine hemadsorption
dc.subjectcytokine storm
dc.subjectsepsis
dc.titleComparison of Cytokine Hemadsorption as an Immunomodulator Therapy in COVID-19 Patients with and without Bacterial Sepsis
dc.typearticle
dspace.entity.typePublication
local.avesis.iddc7b67c4-e7df-4be4-90c1-05c2db8f877a
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
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