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İnvestigation of the Efficacy of Aminoguanidine in an Experimental Rat Model with Isolated Bilateral Pulmonary Contusion Due To Blunt Thoracic Trauma

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dc.contributor.authorAtik, Dilek
dc.contributor.authorTaşlıdere, Bahadır
dc.contributor.institutionauthorTAŞLIDERE, BAHADIR
dc.date.accessioned2020-01-23T20:59:24Z
dc.date.available2020-01-23T20:59:24Z
dc.date.issued2019-12-01T00:00:00Z
dc.description.abstractİntroduction:In severe thoracic trauma pulmonary contusions are almost inevitable are associated with high morbidity and mortality. In this study we aimed to evaluate the antioxidant activity of aminoguanidine in pulmonary contusion.Method:Sixty-three Sprague-male rats were used. Sham and aminoguanidine groups were exposed to isolated blunt thoracic trauma with a force of 1,512 joules. Aminoguanidine was administered intraperitoneally at a dose of 100 mg/kg 3 hours before the trauma and on the 1. and 2. day after the trauma. The contusion group was exposed to blunt thoracic trauma only. In all groups, arterial blood gas analysis and catalase and NO levels were done on the 0th, 1st, 2nd and 3rd days.Results:PO2 levels were higher in the sham group compared to the contusion group, without statistical significance. On the third day, SaO2 levels were higher in the AG group compared to the contusion group. SaO2 levels were comparable in the AG and sham groups on days 1, 2 and 3. There was no difference between the PaO2 levels of the contusion and sham groups on the 2nd and 3rd days. There was no difference between the PaO2 levels of the AG and sham groups on the 1st, 2nd and 3rd days. We found no difference between the PaCO2 levels of the contusion and sham groups on the 0-3 days. There was no difference between the PaCO2 levels of the AG and sham groups on the 1st, 2nd and 3rd days. No difference was observed between the PaCO2 levels of the AG and contusion groups on the 1st, 2nd and 3rd days. No significant difference was found between the NO levels of the sham and the contusion groups on day 0. There was a significant difference between the sham and contusion groups on the 1st, 2nd and 3rd days. There was no statistically significant difference between the catalase enzyme activities of the sham and AG groups.Conclusion:In our study, we showed that the use of aminoguanidine did not significantly reduce the severity of pulmonary contusion and the inflammatory reaction induced by thoracic trauma in rats.
dc.identifier.citationAtik D., Taşlıdere B., -İnvestigation of the Efficacy of Aminoguanidine in an Experimental Rat Model with Isolated Bilateral Pulmonary Contusion Due To Blunt Thoracic Trauma-, Eurasian Journal of Critical Care, cilt.1, ss.115-120, 2019
dc.identifier.urihttps://openaccess.bezmialem.edu.tr/handle/20.500.12645/13489
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleİnvestigation of the Efficacy of Aminoguanidine in an Experimental Rat Model with Isolated Bilateral Pulmonary Contusion Due To Blunt Thoracic Trauma
dc.typeArticle
dspace.entity.typePublication
local.avesis.id733b1731-0176-4143-a65b-4c0ed8d113f4
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational0
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relation.isAuthorOfPublication.latestForDiscoveryc3a1f40b-abfb-41fc-ac37-c541ff5cc173
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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