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Comparison of antioxidant, anticholinesterase, and antidiabetic activities of three curcuminoids isolated from Curcuma longa L.

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dc.contributor.authorKalaycıoğlu, Zeynep
dc.contributor.authorGazioglu, IŞIL
dc.contributor.authorErim, F. Bedia
dc.contributor.institutionauthorGAZİOĞLU, IŞIL
dc.date.accessioned2019-10-05T13:40:39Z
dc.date.available2019-10-05T13:40:39Z
dc.date.issued2017-01-01
dc.description.abstractAntioxidant, anticholinesterase and antidiabetic activities of three curcuminoids isolated from the Curcuma longa were simultaneously tested and compared in this study. The highest antioxidant power was detected for curcumin with the applied methods. The drug potentials of curcuminoids for Alzheimer-s disease were controlled. Bisdemethoxycurcumin (BDMC) showed substantial inhibitory activity. The activity of demethoxycurcumin (DMC) followed BDMC, whereas curcumin showed very little acetylcholinesterase inhibition activity. Antidiabetic activity of curcuminoids was evaluated by their -glucosidase inhibitory activities. All curcuminoids show activities with decreasing order as BDMC>curcumin>DMC. The significant activities of BDMC compared to its isomers and examination of chemical structures of isomers might be a starting point in designing new drugs for Alzheimer-s and Diabetes Mellitus.
dc.description.sponsorshipİstanbul Üniversitesi
dc.identifier10.1007/s12603-018-1032-6
dc.identifier.citationKalaycıoğlu Z., Gazioglu I., Erim F. B. , -Comparison of antioxidant, anticholinesterase, and antidiabetic activities of three curcuminoids isolated from Curcuma longa L.-, NATURAL PRODUCT RESEARCH, cilt.31, ss.2914-2917, 2017
dc.identifier.pubmed28287280
dc.identifier.urihttps://hdl.handle.net/20.500.12645/2702
dc.language.isoen
dc.titleComparison of antioxidant, anticholinesterase, and antidiabetic activities of three curcuminoids isolated from Curcuma longa L.
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameThe journal of nutrition, health & aging
local.avesis.id42037502-8712-46d1-bd1e-7db315f8a044
local.avesis.response2572
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
relation.isAuthorOfPublication336380d2-70ee-496d-a002-08059f9da500
relation.isAuthorOfPublication.latestForDiscovery336380d2-70ee-496d-a002-08059f9da500
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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