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Dexpanthenol and ascorbic acid ameliorate colistin-induced nephrotoxicity in rats.

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dc.contributor.authorAslan, T
dc.contributor.authorGuler, E M
dc.contributor.authorDundar, T
dc.contributor.authorCakir, A
dc.contributor.authorGulgec, A S
dc.contributor.authorHuseyinbas, O
dc.contributor.authorCelikten, M
dc.contributor.authorCoban, G
dc.contributor.authorHakyemez, I N
dc.contributor.authorKocyigit, ABDÜRRAHİM
dc.contributor.authorDurdu, B
dc.contributor.institutionauthorDÜNDAR, TOLGA TURAN
dc.contributor.institutionauthorKOÇYİĞİT, ABDÜRRAHİM
dc.date.accessioned2021-02-19T20:59:14Z
dc.date.available2021-02-19T20:59:14Z
dc.date.issued2021-01-01T00:00:00Z
dc.description.abstractObjective: Colistin is a potent antibiotic which is mainly preferred in the treatment of multidrug-resistant (MDR) gram-negative bacilli. However, due to the increased risk of acute kidney injury following its use, the clinical application is limited. This nephrotoxicity is known to be induced by oxidative stress and related inflammation. In this study on rats, potent antioxidants Dexpanthenol (DEX) and Ascorbic acid (Vit C) have been administered in combination with Colistin to find out whether they would weaken Colistin's nephrotoxic effects. Materials and methods: Inflammation biomarkers were studied with enzyme-linked immunosorbent assay (ELISA) kits, and oxidative stress biomarkers were studied with different photometric methods in blood and tissue samples taken after treatment with DEX and Vit C in rats with colistin nephrotoxicity. In addition, inflammation and necrosis in the kidney tissues were examined pathologically. Results: It has been observed in the serum and tissue samples that DEX and Vit C decrease oxidative stress and inflammation biomarkers, therefore acting as nephroprotective agents. Conclusions: These compounds have been found to ameliorate the nephrotoxic effects of Colistin, which were demonstrated in the rats treated with Colistin, as well as the combinations.
dc.identifier.doi10.26355/eurrev_202101_24671
dc.identifier.pubmed33577057
dc.identifier.urihttp://hdl.handle.net/20.500.12645/28454
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectColistin-induced nephrotoxicity
dc.subjectDexpanthenol
dc.subjectAscorbic acid
dc.subjectOxidative stress
dc.subjectInflammation
dc.titleDexpanthenol and ascorbic acid ameliorate colistin-induced nephrotoxicity in rats.
dc.typeArticle
dspace.entity.typePublication
local.avesis.idf0b0b32c-e5d7-40da-b400-60a2cc2e93e9
local.publication.isinternational1
relation.isAuthorOfPublication9efe18e9-8f9c-4993-8717-39f7347f9791
relation.isAuthorOfPublication75babbd2-f46b-4121-aa00-54d883a6f907
relation.isAuthorOfPublication.latestForDiscovery75babbd2-f46b-4121-aa00-54d883a6f907
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