Publication:
The genotoxic potentials of some atypical antipsychotic drugs on human lymphocytes

No Thumbnail Available
Date
2012-05-01T00:00:00Z
Authors
Togar, Basak
Turkez, Hasan
TATAR, Abdulgani
Kirkpinar, İSMET
HACIMÜFTÜOĞLU, Ahmet
GEYİKOĞLU, Fatime
KELEŞ, Mevlüt Sait
Dirican, Ebubekir
Journal Title
Journal ISSN
Volume Title
Publisher
Research Projects
Organizational Units
Journal Issue

Metrics

Search on Google Scholar

Abstract
Olanzapine (OLZ), risperidone (RPD) and quetiapine (QTP) are atypical antipsychotic drugs and are commonly used for the treatments of schizophrenia and bipolar disorders. However, recent reports indicated that these drugs could exhibit toxic effects on nervous and cardiovascular systems. To our best knowledge, there are scarce data considering the genotoxic damage potentials of OLZ, RPD and QTP on human lymphocyte culture system. Therefore, in this study, the genotoxic potentials of OLZ, RPD and QTP (0-400 mg/L) have been evaluated in human whole blood cultures (WBCs; n = 4). The single cell gel electrophoresis (SCGE) and micronucleus (MN) assays were applied to estimate the DNA damage. The results of the present study indicated that the tested antipsychotic drug did not induce genotoxicity. In fact, the mean values of the total scores of cells showing DNA damage (for SCGE assay) and MN/1000 cell were not found significantly different from the control values (p > 0.05). However, the application of the highest drug concentrations (250 mg/L and above) caused the sterility in lymphocyte cultures. It is concluded that the tested three different atypical antipsychotic drugs can be used safely, but it is necessary to consider the cytotoxic effects that are likely to appear depending on the doses exposed.
Description
Keywords
Citation
Togar B., Turkez H., TATAR A., Kirkpinar İ., HACIMÜFTÜOĞLU A., GEYİKOĞLU F., KELEŞ M. S. , Dirican E., -The genotoxic potentials of some atypical antipsychotic drugs on human lymphocytes-, TOXICOLOGY AND INDUSTRIAL HEALTH, cilt.28, ss.327-333, 2012
Collections
Page Views

0

File Downloads

0

Sustainable Development Goals