Publication:
Evaluation of aggrecan and adipokine levels in temporomandibular joint synovial fluid

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dc.contributor.authorBayındır Ş.
dc.contributor.authorYILMAZ ASAN C.
dc.contributor.authorDEMİRBAŞ A. E.
dc.contributor.authorBARLAK KETİ D.
dc.contributor.authorKÜTÜK N.
dc.contributor.institutionauthorKÜTÜK, NÜKHET
dc.date.accessioned2023-01-08T22:59:31Z
dc.date.available2023-01-08T22:59:31Z
dc.date.issued2022-05-01
dc.description.abstract© 2021The aim of this study was to investigate the effect various mediators in synovial fluid (SF) on the pathogenesis of temporomandibular disorders (TMD) and to evaluate the relationship between clinical and radiological features of temporomandibular joint (TMJ) diseases. Patients who had received SF sample during arthrocentesis because of TMD were included in this study. Clinical and radiological records were evaluated retrospectively. Enzyme-Linked ImmunoSorbent Assay (ELISA) method was used for analysis of aggrecan, adiponectin, resistin, apelin, Vascular Endothelial Growth Factor (VEGF) and Prostaglandin E2 (PGE2) in SFs. 59 joints of 41 patients were included in the study. Anterior disc displacement with reduction (ADDwR) was detected in 22 joints, anterior disc displacement without reduction (ADDwoR) was detected in 29 joints and osteoarthritis (OA) in 8. In OA group, PGE2 level was significantly higher than the other groups (p = 0.029). Aggrecan and PGE2 levels were statistically higher in joints with localized pain (p = 0.030, p = 0.029). The aggrecan level was statistically significant higher in patients who had degenerative changes in radiological examinations (p = 0.044). Resistin was correlated with PGE2 and aggrecan (p = 0.011), and apelin showed positive correlation with VEGF (p˂0.001). The detection of aggrecan and adipokines in SF may be a precursor of degenerative joint disease and it should be taken into account that the presence of localized pain in the joint area may be an early sign of degenerative changes.
dc.identifier.citationBayındır Ş., YILMAZ ASAN C., DEMİRBAŞ A. E., BARLAK KETİ D., KÜTÜK N., "Evaluation of aggrecan and adipokine levels in temporomandibular joint synovial fluid", Journal of Cranio-Maxillofacial Surgery, cilt.50, sa.5, ss.432-438, 2022
dc.identifier.doi10.1016/j.jcms.2021.12.001
dc.identifier.endpage438
dc.identifier.issn1010-5182
dc.identifier.issue5
dc.identifier.pubmed35491326
dc.identifier.startpage432
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85129799295&origin=inward
dc.identifier.urihttps://hdl.handle.net/20.500.12645/34927
dc.identifier.volume50
dc.relation.ispartofJournal of Cranio-Maxillofacial Surgery
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectCerrahi Tıp Bilimleri
dc.subjectKulak Burun Boğaz
dc.subjectDiş Hekimliği
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectSurgery Medicine Sciences
dc.subjectOtolaryngology
dc.subjectDentistry
dc.subjectHealth Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectCERRAHİ
dc.subjectDİŞ HEKİMLİĞİ, ORAL CERRAHİ VE TIP
dc.subjectKULAK BURUN BOĞAZ
dc.subjectClinical Medicine (MED)
dc.subjectCLINICAL MEDICINE
dc.subjectSURGERY
dc.subjectDENTISTRY, ORAL SURGERY & MEDICINE
dc.subjectOTORHINOLARYNGOLOGY
dc.subjectCerrahi
dc.subjectAğız Cerrahisi
dc.subjectSurgery
dc.subjectOral Surgery
dc.subjectOtorhinolaryngology
dc.subjectAdipokines
dc.subjectAggrecan
dc.subjectDegeneration
dc.subjectOsteoarthritis
dc.subjectSynovial fluid
dc.titleEvaluation of aggrecan and adipokine levels in temporomandibular joint synovial fluid
dc.typearticle
dspace.entity.typePublication
local.avesis.idf3b2eb88-647e-4dd2-9950-17184aeff44e
relation.isAuthorOfPublication908c31f8-027f-44c3-9992-1f8b42ac3367
relation.isAuthorOfPublication.latestForDiscovery908c31f8-027f-44c3-9992-1f8b42ac3367
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