Publication:
Oxidative Status and DNA Damage in Chidren With Marasmic Malnutrition

dc.contributor.authorCELIK, Maruf
dc.contributor.authorSermatov, Kabil
dc.contributor.authorAbuhandan, Mahmut
dc.contributor.authorZeyrek, Dost
dc.contributor.authorKocyigit, ABDÜRRAHİM
dc.contributor.authorIscan, Akin
dc.contributor.institutionauthorKOÇYİĞİT, ABDÜRRAHİM
dc.date.accessioned2020-10-29T22:20:57Z
dc.date.available2020-10-29T22:20:57Z
dc.date.issued2012-01-01T00:00:00Z
dc.description.abstractMalnutrition as a lack of several substances containing antioxidants such as vitamins and micronutrients, while showing a predisposition for lipid peroxidation and DNA damage, is also characterized by a slowing down of the metabolic processes, which may then have protective properties against DNA damage due to a reduction in endogenous free radical production. This study aimed to examine the oxidative status and DNA damage in cases of marasmus. The study comprised 28 infants aged 624 months with marasmus only and 28 age-matched healthy infants. DNA damage was examined by the alkali single cell electrophoresis method (Comet assay) on mononuclear leukocytes. The total oxidant status (TOS) and total antioxidant status (TAS) were measured by colormetric auto-analyzer and the oxidative stress index (OSI) was calculated. The TOS, TAS, and OSI levels of the patient group were found to be significantly lower compared to the control group (P 0.05). The findings of this study showed that in marasmus cases, the oxidative and antioxidative processes, which have a counteractive effect, decreased together. The other results of the study indicate that there is no increase in DNA damage in marasmus cases. J. Clin. Lab. Anal. 26:161-166, 2012. (c) 2012 Wiley Periodicals, Inc.
dc.identifier.citationCELIK M., Sermatov K., Abuhandan M., Zeyrek D., Kocyigit A., Iscan A., -Oxidative Status and DNA Damage in Chidren With Marasmic Malnutrition-, JOURNAL OF CLINICAL LABORATORY ANALYSIS, cilt.26, ss.161-166, 2012
dc.identifier.doi10.1002/jcla.21505
dc.identifier.scopus84861474182
dc.identifier.urihttp://hdl.handle.net/20.500.12645/26559
dc.identifier.wosWOS:000304397200007
dc.titleOxidative Status and DNA Damage in Chidren With Marasmic Malnutrition
dc.typeArticle
dspace.entity.typePublication
local.avesis.idae0d81d1-c8b0-424f-9ff4-dfaff9be5139
local.publication.goal02 - Açlığa Son
local.publication.isinternational1
relation.isAuthorOfPublication75babbd2-f46b-4121-aa00-54d883a6f907
relation.isAuthorOfPublication.latestForDiscovery75babbd2-f46b-4121-aa00-54d883a6f907
relation.isGoalOfPublication5246edf8-60d4-4a7b-9a27-c73e4a636141
relation.isGoalOfPublication.latestForDiscovery5246edf8-60d4-4a7b-9a27-c73e4a636141
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