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Role of the beta(3)-adrenergic receptor subtype in catecholamine-induced myocardial remodeling

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dc.contributor.authorMutlu, Gizem Kayki
dc.contributor.authorInan, Ebru Arioglu
dc.contributor.authorKaraomerlioglu, Irem
dc.contributor.authorAltan, VECDİ MELİH
dc.contributor.authorYERSAL, NİLGÜN
dc.contributor.authorKORKUSUZ, PETEK
dc.contributor.authorRocchetti, Marcella
dc.contributor.authorZaza, Antonio
dc.contributor.institutionauthorALTAN, VECDİ MELİH
dc.date.accessioned2019-10-05T14:45:39Z
dc.date.available2019-10-05T14:45:39Z
dc.date.issued2018-09-01
dc.description.abstractbeta(3)-Adrenoceptors (AR) stimulate cardiac Na+/K+ pump in healthy hearts. beta(3)-ARs are upregulated by persistent sympathetic hyperactivity; however, their effect on Na+/K+ ATPase activity and ventricular function in this condition is still unknown. Here, we investigate preventive effects of additional beta(3)-AR activation (BRL) on Na+/K+ ATPase activity and in vivo hemodynamics in a model of noradrenaline-induced hypertrophy. Rats received NA or NA plus simultaneously administered BRL in vivo infusion for 14 days; their cardiac function was investigated by left ventricular pressure-volume analysis. Moreover, fibrosis and apoptosis were also assessed histologically. NA induced an hypertrophic pattern, as detected by morphological, histological, and biochemical markers. Additional BRL exposure reversed the hypertrophic pattern and restored Na+/K+ ATPase activity. NA treatment increased systolic function and depressed diastolic function (slowed relaxation). Additional BRL treatment reversed most NA-induced hemodynamic changes. NA decreased Na+/K+ pump alpha 2 subunit expression selectively, a change also reversed by additional BRL treatment. Increasing beta(3)-AR stimulation may prevent the consequences of chronic NA exposure on Na+/K+ pump and in vivo hemodynamics. beta(3)-AR agonism may thus represent a new therapeutic strategy for pharmacological modulation of hypertrophy under conditions of chronically enhanced sympathetic activity.
dc.identifier
dc.identifier.citationMutlu G. K. , Inan E. A. , Karaomerlioglu I., Altan V. M. , YERSAL N., KORKUSUZ P., Rocchetti M., Zaza A., -Role of the beta(3)-adrenergic receptor subtype in catecholamine-induced myocardial remodeling-, MOLECULAR AND CELLULAR BIOCHEMISTRY, cilt.446, ss.149-160, 2018
dc.identifier.doi10.1007/s11010-018-3282-3
dc.identifier.pubmed29363058
dc.identifier.scopus85040868269
dc.identifier.urihttps://hdl.handle.net/20.500.12645/4676
dc.identifier.wosWOS:000440595700015
dc.language.isoen
dc.titleRole of the beta(3)-adrenergic receptor subtype in catecholamine-induced myocardial remodeling
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameTÜRK KARDİYOLOJİ DERNEĞİ ARŞİVİ
local.avesis.id72bf6d34-2a6d-4b72-8518-970bf7e21531
local.avesis.response4546
local.publication.isinternational1
relation.isAuthorOfPublicatione37c2bd0-23e0-4f76-9976-6414ab3c6ab9
relation.isAuthorOfPublication.latestForDiscoverye37c2bd0-23e0-4f76-9976-6414ab3c6ab9
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