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Understanding and Targeting the Colon Cancer Pathogenesis: A Molecular Perspective

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dc.contributor.authorKHAN I.
dc.contributor.institutionauthorKHAN, IMRAN
dc.date.accessioned2023-01-08T22:21:15Z
dc.date.available2023-01-08T22:21:15Z
dc.date.issued2022-01-01
dc.description.abstractColorectal cancer (CRC) one of the leading cause of cancer-related deaths worldwide. With the presently available knowledge on CRC, it is understood that the underlying is a complex process. The complexity of CRC lies in aberrant activation of several cellular signaling pathways that lead to activation and progression of CRC. In this context, recent studies have pointed towards the role of developmental pathways like; hedgehog (HH), wingless-related integration site (WNT/??-catenin) and Notch pathways that play a crucial role in maintenance and homeostasis of colon epithelium. Moreover, the deregulation of these signaling pathways has also been associated with the pathogenesis of CRC. Therefore, in the search for better therapeutic options, these pathways have emerged as potential targets. The present review attempts to highlight the role of HH, WNT/??-catenin and Notch pathways in colon carcinogenesis.
dc.identifier.citationKHAN I., "Understanding and Targeting the Colon Cancer Pathogenesis: A Molecular Perspective", BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.58, 2022
dc.identifier.doi10.1590/s2175-97902022e20354
dc.identifier.issn1984-8250
dc.identifier.urihttps://hdl.handle.net/20.500.12645/34778
dc.identifier.volume58
dc.relation.ispartofBRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEczacılık
dc.subjectTemel Eczacılık Bilimleri
dc.subjectYaşam Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectTemel Bilimler
dc.subjectPharmacology and Therapeutics
dc.subjectBasic Pharmaceutics Sciences
dc.subjectLife Sciences
dc.subjectHealth Sciences
dc.subjectNatural Sciences
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectPHARMACOLOGY & PHARMACY
dc.subjectPHARMACOLOGY & TOXICOLOGY
dc.subjectLife Sciences (LIFE)
dc.subjectFarmakoloji
dc.subjectFarmakoloji, Toksikoloji ve Eczacılık (çeşitli)
dc.subjectGenel Farmakoloji, Toksikoloji ve Eczacılık
dc.subjectFarmakoloji (tıbbi)
dc.subjectİlaç Rehberleri
dc.subjectPharmacy
dc.subjectPharmacology
dc.subjectPharmacology, Toxicology and Pharmaceutics (miscellaneous)
dc.subjectGeneral Pharmacology, Toxicology and Pharmaceutics
dc.subjectPharmacology (medical)
dc.subjectDrug Guides
dc.subjectHedgehog
dc.subjectWNT
dc.subject?-catenin
dc.subjectNotch
dc.subjectColon cancer
dc.subjectMolecular targets
dc.subjectGLI TRANSCRIPTION FACTORS
dc.subjectSTEM-CELL
dc.subjectCOLORECTAL-CANCER
dc.subjectBETA-CATENIN
dc.subjectSIGNALING PATHWAYS
dc.subjectHEDGEHOG PATHWAY
dc.subjectNOTCH
dc.subjectACTIVATION
dc.subjectEXPRESSION
dc.titleUnderstanding and Targeting the Colon Cancer Pathogenesis: A Molecular Perspective
dc.typearticle
dspace.entity.typePublication
local.avesis.ide54ad3d2-1e04-4720-9ba9-7d718669c13b
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
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