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Diagnostic performance of apparent diffusion coefficient values for the differentiation of intrahepatic cholangiocarcinoma from gastrointestinal adenocarcinoma liver metastases

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dc.contributor.authorYilmaz, TEMEL FATİH
dc.contributor.authorGultekin, Mehmet Ali
dc.contributor.authorTurk, Hacı Mehmet
dc.contributor.authorCesme, Dilek Hacer
dc.contributor.authorBesiroglu, Mehmet
dc.contributor.authorSimsek, Melih
dc.contributor.authorToprak, Huseyin
dc.contributor.authorAlkan, ALPAY
dc.contributor.institutionauthorYILMAZ, TEMEL FATİH
dc.contributor.institutionauthorTÜRK, HACI MEHMET
dc.contributor.institutionauthorÇEŞME, DİLEK HACER
dc.contributor.institutionauthorŞİMŞEK, MELİH
dc.contributor.institutionauthorALKAN, ALPAY
dc.contributor.institutionauthorTOPRAK, HÜSEYİN
dc.date.accessioned2021-12-29T20:59:12Z
dc.date.available2021-12-29T20:59:12Z
dc.date.issued2021-12-22T00:00:00Z
dc.description.abstractBackground: We aimed to investigate whether there is a difference between intrahepatic cholangiocarcinoma (IHCC) and liver metastases of gastrointestinal system (GIS) adenocarcinoma in terms of apparent diffusion coefficient (ADC) values. Patients and methods: From January 2018 to January 2020, we retrospectively examined 64 consecutive patients with liver metastases due to gastrointestinal system adenocarcinomas and 13 consecutive IHCC in our hospital's medical records. After exclusions, fifty-three patients with 53 liver metastases and 10 IHCC were included in our study. We divided the patients into two groups as IHCC and liver metastases of GIS adenocarcinoma. For mean apparent diffusion coefficient (ADCmean) values, the region of interests (ROI) was placed in solid portions of the lesions. ADCmean values of groups were compared. Results: The mean age of IHCC group was 62.50 ± 13.49 and mean age of metastases group was 61.15 ± 9.18. ADCmean values were significantly higher in the IHCC group compared to the metastatic group (p < 0.001). ROC curves method showed high diagnostic accuracy (AUC = 0.879) with cut-off value of < 1178 x 10-6 mm2/s for ADCmean (Sensitivity = 90.57, Specificity = 70.0, positive predictive value [PPV] = 94.1, negative predictive value [NPV] = 58.3) in differentiating adenocarcinoma metastases from IHCC. Conclusions: The present study results suggest that ADC values have a potential role for differentiation between IHCC and GIS adenocarcinoma liver metastases which may be valuable for patient management.
dc.identifier.doi10.2478/raon-2021-0052
dc.identifier.pubmed34957725
dc.identifier.urihttp://hdl.handle.net/20.500.12645/29919
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMRI
dc.subjectapparent diffusion coefficient
dc.subjectcholangiocarcinoma
dc.subjectdiffusion weighted image
dc.subjectgatrointestinal system
dc.subjectliver metastases
dc.titleDiagnostic performance of apparent diffusion coefficient values for the differentiation of intrahepatic cholangiocarcinoma from gastrointestinal adenocarcinoma liver metastases
dc.typeArticle
dspace.entity.typePublication
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