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Comparison of intraperitoneal and intratesticular ozone therapy for the treatment of testicular ischemia- reperfusion injury in rats

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dc.contributor.authorMete, Fatih
dc.contributor.authorTarhan, Huseyin
dc.contributor.authorCelik, Orcun
dc.contributor.authorAkarken, Ilker
dc.contributor.authorVural, Kamil
dc.contributor.authorEkin, Rahmi Gokhan
dc.contributor.authorAydemir, Isil
dc.contributor.authorIlbey, YUSUF ÖZLEM
dc.contributor.institutionauthorİLBEY, YUSUF ÖZLEM
dc.date.accessioned2022-01-27T21:00:16Z
dc.date.available2022-01-27T21:00:16Z
dc.date.issued2017-01-01T00:00:00Z
dc.description.abstractWe compare the efficacy of intratesticular ozone therapy with intraperitoneal ozone therapy in an experimental rat model. For this purpose, 24 rats were divided into four groups including sham-operated, torsion/detorsion, torsion/detorsion plus intraperitoneal ozone (O-P), and torsion/detorsion plus intratesticular ozone (O-IT). The O-IP ozone group received a 4 mg kg(-1) intraperitoneal injection of ozone, and the O-IT group received the same injection epididymally. At 4 h after detorsion, the rats were sacrificed and orchiectomy materials were assessed histopathologically. Spermatogenesis in the seminiferous tubules and damage to the Sertoli cells were histopathologically evaluated in the testes using the Johnsen scoring system. i-NOS and e-NOS activities in the testis tissue were also evaluated. Torsion-detorsion caused a decreased Johnsen score and increased apoptosis of spermatogonial and Sertoli cells. Ozone injection prevented increases in Johnsen score and i-NOS level. e-NOS level of the O-IP group was significantly lower than that of the O-IP group, and i-NOS level of the O-IT group was significantly lower than that of the O-IP group. Local ozone therapy is more effective than systemic ozone therapy at improving IRI-related testicular torsion. Our study is the first to show that the efficacy of intratesticular implementation of ozone therapy is higher than that of intraperitoneal ozone therapy.
dc.identifier.citationMete F., Tarhan H., Celik O., Akarken I., Vural K., Ekin R. G. , Aydemir I., Ilbey Y. Ö. , -Comparison of intraperitoneal and intratesticular ozone therapy for the treatment of testicular ischemia- reperfusion injury in rats-, ASIAN JOURNAL OF ANDROLOGY, cilt.19, sa.1, ss.43-46, 2017
dc.identifier.doi10.4103/1008-682x.171570
dc.identifier.scopus85008705370
dc.identifier.urihttp://hdl.handle.net/20.500.12645/30337
dc.identifier.wosWOS:000392108300008
dc.titleComparison of intraperitoneal and intratesticular ozone therapy for the treatment of testicular ischemia- reperfusion injury in rats
dc.typeArticle
dspace.entity.typePublication
local.avesis.idcd5c703b-ab32-4464-b2fe-d959c465782e
local.publication.isinternational1
relation.isAuthorOfPublicatione166fdca-de94-48b0-a771-14053e70c6ca
relation.isAuthorOfPublication.latestForDiscoverye166fdca-de94-48b0-a771-14053e70c6ca
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