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Effects of Orally Consumed <i>Rosa damascena</i> Mill. Hydrosol on Hematology, Clinical Chemistry, Lens Enzymatic Activity, and Lens Pathology in Streptozotocin-Induced Diabetic Rats.

dc.contributor.authorDemirbolat, İ
dc.contributor.authorEkinci, C
dc.contributor.authorNuhoğlu, F
dc.contributor.authorYıldız, PELİN
dc.contributor.authorGeçer, MÖ
dc.contributor.institutionauthorKARTAL, MURAT
dc.contributor.institutionauthorYILDIZ, PELİN
dc.date.accessioned2020-01-16T20:59:57Z
dc.date.available2020-01-16T20:59:57Z
dc.date.issued2019-11-10T00:00:00Z
dc.description.abstractDiabetes mellitus is a multisystemic metabolic disorder that may affect the eyes, kidneys, vessels, and heart. Chronic hyperglycemia causes non-enzymatic glycation of proteins and elevation of the polyol pathway resulting in oxidative stress that damages organs. The current study aimed to investigate the dose-dependent effects of orally consumed Rosa damascena Mill. hydrosol on hematology, clinical biochemistry, lens enzymatic activity, and lens pathology in streptozotocin (STZ)-induced diabetic rats. Diabetes was induced into male Sprague-Dawley rats by intraperitoneal administration of STZ (40 mg/kg body weight). Rose hydrosols containing 1515 mg/L and 500 mg/L total volatiles (expressed as citronellol) were introduced to rats orally for 45 days. Consumption of 1515 mg/L volatile containing rose hydrosol successfully ameliorated hematologic, hepatic, and renal functions. Hydrosols also attenuated hyperglycemia and decreased the advanced glycation end-product formation in a dose-dependent manner. Rose hydrosol components significantly increased the lens enzymatic activities of glutathione peroxidase and decreased the activity of aldose reductase to prevent cataractogenesis. Histopathological examinations of rat lenses also indicated that increasing the dose of rose hydrosol had a protective effect on lenses in diabetic conditions. Additionally, in silico modeling of aldose reductase inhibition with rose hydrosol volatiles was carried out for extrapolating the current study to humans. The present results suggest that rose hydrosol exerts significant protective properties in diabetes mellitus and has no toxic effect on all studied systems in healthy test groups.en
dc.identifier.citationDemirbolat İ., Ekinci C., Nuhoğlu F., Kartal M., Yıldız P., Geçer M., -Effects of Orally Consumed <i>Rosa damascena</i> Mill. Hydrosol on Hematology, Clinical Chemistry, Lens Enzymatic Activity, and Lens Pathology in Streptozotocin-Induced Diabetic Rats.-, Molecules (Basel, Switzerland), cilt.24, 2019
dc.identifier.doi10.3390/molecules24224069
dc.identifier.pubmed31717650
dc.identifier.scopus85074924745
dc.identifier.urihttps://openaccess.bezmialem.edu.tr/handle/20.500.12645/13314
dc.identifier.wosWOS:000501529700058
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleEffects of Orally Consumed <i>Rosa damascena</i> Mill. Hydrosol on Hematology, Clinical Chemistry, Lens Enzymatic Activity, and Lens Pathology in Streptozotocin-Induced Diabetic Rats.
dc.typeArticle
dspace.entity.typePublication
local.avesis.id67182ec2-ebde-488b-ad97-4908b0bade78
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isAuthorOfPublicationb30ec030-5f34-4c8b-814e-a7131d524a0a
relation.isAuthorOfPublication4c9a734d-36ee-4704-9e15-7012fd2ca3fb
relation.isAuthorOfPublication.latestForDiscoveryb30ec030-5f34-4c8b-814e-a7131d524a0a
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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