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The effect of different concentrations of topical ozone administration on bone formation in orthopedically expanded suture in rats

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dc.contributor.authorBÜYÜK, SÜLEYMAN KUTALMIŞ
dc.contributor.authorRamoglu, Sabri Ilhan
dc.contributor.authorSonmez, Mehmet Fatih
dc.date.accessioned2020-10-22T18:34:08Z
dc.date.available2020-10-22T18:34:08Z
dc.date.issued2016-06-01T00:00:00Z
dc.description.abstractBackground/objective: The aim of this study was to investigate the effects of different concentrations of ozone (O 3 ) therapy on bone regeneration in response to an expansion of the inter-premaxillary suture in rats. Materials and methods: Forty-eight Wistar rats were randomly divided into four groups ( n = 12). In groups I, II, and III, 1ml of O 3 at 10, 25, and 40 µg/ml was injected at the premaxillary suture, respectively. In group IV (control group), 1ml of saline solution was injected at the same point during the expansion procedure for 5 days. Bone regeneration in the suture was evaluated histomorphometrically. The area of new bone and fibrotic area, the number of osteoblasts and osteoclasts, and the amount of vascularity were measured and compared. The density of the newly formed bone in the expansion area was measured by using cone beam computed tomography. Data were analyzed using the Kruskal–Wallis one-way analysis of variance and post hoc Student-Newman–Keuls tests. Results: New bone area, fibrotic area, osteoblast and osteoclast numbers, and the amount of vascularity were significantly higher in experimental groups compared with the control group ( P < 0.001). The density of newly formed bone ( P < 0.001), new bone formation ( P = 0.009), number of capillaries ( P < 0.001), number of osteoclasts ( P = 0.016), and number of osteoblasts ( P < 0.001) in the maxillary sutures were highest in the 25 μg/ml O 3 group compared with the other experimental groups and control group. Conclusions/implications: The application of O 3 therapy can stimulate bone regeneration in an orthopedically expanded inter-premaxillary suture during both the expansion and retention periods.
dc.description.sponsorshipTürkiye Bilimsel Ve Teknolojik Araştırma Kurumu ( Tübitak )
dc.identifier.citationBÜYÜK S. K. , Ramoglu S. I. , Sonmez M. F. , -The effect of different concentrations of topical ozone administration on bone formation in orthopedically expanded suture in rats-, EUROPEAN JOURNAL OF ORTHODONTICS, cilt.38, ss.281-285, 2016
dc.identifier.doi10.1093/ejo/cjv045
dc.identifier.pubmed26136437
dc.identifier.scopus84973571878
dc.identifier.urihttp://hdl.handle.net/20.500.12645/24175
dc.identifier.urihttps://academic.oup.com/ejo/article/38/3/281/2599889
dc.identifier.wosWOS:000377921000009
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectComputed tomography
dc.titleThe effect of different concentrations of topical ozone administration on bone formation in orthopedically expanded suture in rats
dc.typeArticle
dspace.entity.typePublication
local.avesis.id8ed76316-379d-4a23-8eef-a3b49eafa92f
local.publication.isinternational1
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