Publication:
EFFECTS OF <i>VACCINIUM MYRTILLUS</i> L. EXTRACT ON TNF-α-INDUCED INFLAMMATION THROUGH HUMAN PARAOXONASES

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dc.contributor.authorBalbal B.
dc.contributor.authorBitmez B.
dc.contributor.authorAlbayrak I. G.
dc.contributor.authorGultekin S. K.
dc.contributor.authorAkalin E.
dc.contributor.authorSalihler K.
dc.contributor.authorKARTAL M.
dc.contributor.authorATASEVER ARSLAN B.
dc.date.accessioned2024-08-06T21:50:29Z
dc.date.available2024-08-06T21:50:29Z
dc.date.issued2023-10-01
dc.description.abstractCardiovascular diseases (CVDs) is a leading cause of death worldwide, and is characterized by a range of conditions that affect the heart and blood vessels. The extract of Vaccinium myrtillus L. fruit has been found to have cardioprotective effect. Human paraoxonases ( PON1 , PON2 , PON3 ) genes play an important role in protecting against the development of CVDs by acting as antioxidants and anti-inflammatory agents. The present study aimed to investigate the chemical constituents and cardioprotective effects of V. myrtillus L. extract on TNF- alpha inflammation and oxidative stress in ECV-304 human endothelial cell line and the potential role of human paraoxonases in these effects. The results indicated that V. myrtillus L. extract has cardioprotective effects against inflammation and oxidative stress in ECV-304 cells, and these effects may be mediated through the upregulation of PON1 , PON2 , and PON3 genes. These findings suggest that V.myrtillus L. may have therapeutic potential for the prevention and treatment of CVDs.
dc.identifier.citationBalbal B., Bitmez B., Albayrak I. G., Gultekin S. K., Akalin E., Salihler K., KARTAL M., ATASEVER ARSLAN B., "EFFECTS OF <i>VACCINIUM MYRTILLUS</i> L. EXTRACT ON TNF-α-INDUCED INFLAMMATION THROUGH HUMAN PARAOXONASES", REVUE ROUMAINE DE CHIMIE, sa.10-12, 2023
dc.identifier.doi10.33224/rrch.2023.68.10-12.11
dc.identifier.issn0035-3930
dc.identifier.issue10-12
dc.identifier.urihttps://avesis.bezmialem.edu.tr/api/publication/534d763c-4266-4315-95ec-75cb34922c62/file
dc.identifier.urihttps://hdl.handle.net/20.500.12645/39451
dc.identifier.wosWOS:001266621800011
dc.relation.ispartofREVUE ROUMAINE DE CHIMIE
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectKimya
dc.subjectBiyokimya
dc.subjectAlkoloidler
dc.subjectTemel Bilimler
dc.subjectChemistry
dc.subjectBiochemistry
dc.subjectAlcaloides
dc.subjectNatural Sciences
dc.subjectKİMYA, MULTİDİSİPLİNER
dc.subjectTemel Bilimler (SCI)
dc.subjectCHEMISTRY, MULTIDISCIPLINARY
dc.subjectCHEMISTRY
dc.subjectNatural Sciences (SCI)
dc.subjectKimya (çeşitli)
dc.subjectGenel Kimya
dc.subjectFizik Bilimleri
dc.subjectChemistry (miscellaneous)
dc.subjectGeneral Chemistry
dc.subjectPhysical Sciences
dc.titleEFFECTS OF <i>VACCINIUM MYRTILLUS</i> L. EXTRACT ON TNF-α-INDUCED INFLAMMATION THROUGH HUMAN PARAOXONASES
dc.typeArticle
dspace.entity.typePublication
local.avesis.id534d763c-4266-4315-95ec-75cb34922c62
local.indexed.atWOS

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