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Association of plasma growth arrest-specific protein 6 (Gas6) concentrations with albuminuria in patients with type 2 diabetes

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dc.contributor.authorErek-Toprak, Aybala
dc.contributor.authorBingol-Ozakpinar, Ozlem
dc.contributor.authorKaraca, Zeynep
dc.contributor.authorCikrikcioglu, Mehmet Ali
dc.contributor.authorHursitoglu, Mehmet
dc.contributor.authorUras, Ahmet Riza
dc.contributor.authorAdeli, Khosrow
dc.contributor.authorUras, Fikriye
dc.contributor.institutionauthorÇAĞMAN, ZEYNEP
dc.date.accessioned2020-10-22T15:52:55Z
dc.date.available2020-10-22T15:52:55Z
dc.date.issued2014-06-01T00:00:00Z
dc.description.abstractAims: New biomarkers are required to detect diabetic nephropathy earlier in persons with type 2 diabetes mellitus. Recent experimental studies indicate that growth arrest-specific protein 6 (Gas6) may have a role in pathogenesis of complications associated with diabetes. The objective of the current study is to examine whether plasma Gas6 concentrations are associated with albuminuria in persons with type 2 diabetes mellitus. Methods: About 32 patients with diabetes which have micro or macroalbuminuria, 37 patients with diabetes and normoalbuminuria, and 30 healthy volunteers were recruited. Plasma Gas6 levels were measured by ELISA. Hemoglobin A(1c) (HbA(1c)), serum C reactive protein, fibrinogen and 24-h urine samples for microalbuminuria were analyzed by Primus PDQ, Beckman Coulter Immage 800, STA Compact and Roche Cobas Integra 800 analyzer, respectively. Statistical analysis was performed using SPSS (Statistical Package for Social Sciences) for Windows 11.5. Results: There was a noteworthy difference among the three groups for Gas6 according to the Kruskal-Wallis test (p<0.01). Plasma Gas6 concentrations were higher in patients with micro or macroalbuminuria [20.9 ng/mL (16.7-27.0); median (25-75% percentile)] compared to patients with normoalbuminuria [16.5 ng/mL (13.1-22.9)], and healthy controls [15.3 ng/mL (8.3-33.6)]. Conclusions: In conclusion, this is the first study indicating that plasma Gas6 levels are associated with albuminuria in patients with type 2 diabetes. This study could be considered a starting point to focus on the association between Gas6 and diabetic nephropathy.
dc.identifier.citationErek-Toprak A., Bingol-Ozakpinar O., Karaca Z., Cikrikcioglu M. A. , Hursitoglu M., Uras A. R. , Adeli K., Uras F., -Association of plasma growth arrest-specific protein 6 (Gas6) concentrations with albuminuria in patients with type 2 diabetes-, RENAL FAILURE, cilt.36, ss.737-742, 2014
dc.identifier.doi10.3109/0886022x.2014.883997
dc.identifier.pubmed
dc.identifier.scopus84901925434
dc.identifier.urihttp://hdl.handle.net/20.500.12645/23566
dc.identifier.urihttps://www.tandfonline.com/loi/irnf20
dc.identifier.wosWOS:000336743500013
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjecttype 2 diabetes
dc.titleAssociation of plasma growth arrest-specific protein 6 (Gas6) concentrations with albuminuria in patients with type 2 diabetes
dc.typeArticle
dspace.entity.typePublication
local.avesis.id41a61a99-32c2-4639-995f-fae83b95b9ad
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isAuthorOfPublication7d0efdce-1dc6-4c7e-89f1-e8f96636efc0
relation.isAuthorOfPublication.latestForDiscovery7d0efdce-1dc6-4c7e-89f1-e8f96636efc0
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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