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Effects of carbon dioxide pneumoperitoneum on exocrine and endocrine functions, and oxidative state of rat pancreas

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dc.contributor.authorSag, Sefa
dc.contributor.authorİMAMOĞLU, MUSTAFA
dc.contributor.authorSARIHAN, HALUK
dc.contributor.authorYULUĞ, ESİN
dc.contributor.authorALVER, AHMET
dc.contributor.authorGEZE SAATÇI, ŞÜKRAN
dc.contributor.authorÇAY, Ali
dc.contributor.institutionauthorÇAY, ALI
dc.date.accessioned2020-10-22T15:55:00Z
dc.date.available2020-10-22T15:55:00Z
dc.date.issued2020-07-01T00:00:00Z
dc.description.abstractWe investigated the effects of increased intra-abdominal pressure during laparoscopy on the endocrine and exocrine functions, oxidative stress and histopathology of the pancreas in rats. We established three experimental groups of eight animals. Group 1 was the untreated control. Forth other two groups, pneumoperitoneum with CO(2)was established for 60 min at 6 mm Hg for group 2 and 12 mm Hg for group 3; groups 2 and 3 animals were allowed to re-perfuse for 30 min. Amylase, glucagon and insulin levels were analyzed in blood samples and insulin:glucagon ratio was calculated. Histopathology and malondialdehyde assay were performed on pancreatic tissue samples. Histological damage scores for vasocongestion were increased significantly in groups 2 and 3 compared to group 1. Histological damage scores for inflammatory cell infiltration were increased significantly in group 3 compared to group 1. Malondialdehyde levels were increased significantly in group 3 compared to group 1. We found no significant differences among groups for serum amylase levels or histological damage scores for hemorrhage. Insulin and glucagon levels, and the insulin:glucagon ratio was increased significantly in group 3 compared to groups 1 and 2. We found that in rats routine laparoscopy caused increased serum insulin and glucagon levels, and histopathological changes that indicated ischemia-reperfusion injury to the pancreas.
dc.identifier.citationSag S., İMAMOĞLU M., SARIHAN H., YULUĞ E., ALVER A., GEZE SAATÇI Ş., ÇAY A., -Effects of carbon dioxide pneumoperitoneum on exocrine and endocrine functions, and oxidative state of rat pancreas-, BIOTECHNIC & HISTOCHEMISTRY, 2020
dc.identifier.doi10.1080/10520295.2020.1789224
dc.identifier.pubmed32643433
dc.identifier.scopus85087842354
dc.identifier.urihttp://hdl.handle.net/20.500.12645/23640
dc.identifier.wosWOS:000547086700001
dc.titleEffects of carbon dioxide pneumoperitoneum on exocrine and endocrine functions, and oxidative state of rat pancreas
dc.typeArticle
dspace.entity.typePublication
local.avesis.id497672c1-db92-454b-8b06-22735c7a8193
local.publication.isinternational1
relation.isAuthorOfPublication28be09fc-1b74-40b6-a69e-55cbf052b2dc
relation.isAuthorOfPublication.latestForDiscovery28be09fc-1b74-40b6-a69e-55cbf052b2dc
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