Publication:
Relationship of white matter hyperintensities with clinical features of seizures in patients with epilepsy

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dc.contributor.authorUslu, Ferda Ilgen
dc.contributor.authorÇetintaş, Elif
dc.contributor.authorAlkan, ALPAY
dc.contributor.authorKolukisa, Mehmet
dc.contributor.institutionauthorUSLU, FERDA
dc.contributor.institutionauthorYURTSEVER, İSMAİL
dc.contributor.institutionauthorALKAN, ALPAY
dc.date.accessioned2021-12-07T20:59:14Z
dc.date.available2021-12-07T20:59:14Z
dc.date.issued2021-11-19T00:00:00Z
dc.description.abstractBackground: Although epilepsy is primarily known as a cortical disorder, there is growing body of research demonstrating white matter alterations in patients with epilepsy. Objective: To investigate the prevalence of white matter hyperintensities (WMH) and its association with seizure characteristics in patients with epilepsy. Methods: The prevalence of WMH in 94 patients with epilepsy and 41 healthy controls were compared. Within the patient sample, the relationship between the presence of WMH and type of epilepsy, frequency of seizures, duration of disease and the number of antiepileptic medications were investigated. Results: The mean age and sex were not different between patients and healthy controls (p>0.2). WMH was present in 27.7% of patients and in 14.6% of healthy controls. Diagnosis of epilepsy was independently associated with the presence of WMH (ß=3.09, 95%CI 1.06-9.0, p=0.039). Patients with focal epilepsy had higher prevalence of WMH (35.5%) than patients with generalized epilepsy (14.7%). The presence of WMH was associated with older age but not with seizure characteristics. Conclusions: WMH is more common in patients with focal epilepsy than healthy controls. The presence of WMH is associated with older age, but not with seizure characteristics.
dc.identifier.doi10.1590/0004-282x-anp-2021-0003
dc.identifier.pubmed34816969
dc.identifier.urihttp://hdl.handle.net/20.500.12645/29700
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEpilepsy
dc.subjectWhite Matter
dc.subjectEpilepsies, Partial
dc.subjectEpilepsy, Generalized
dc.titleRelationship of white matter hyperintensities with clinical features of seizures in patients with epilepsy
dc.typeArticle
dspace.entity.typePublication
local.avesis.id0449e19f-0dab-40dd-93ea-dc2e82b1b827
local.publication.isinternational1
relation.isAuthorOfPublicationd406911e-cc19-4fcf-93a8-cff8677e582a
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relation.isAuthorOfPublication.latestForDiscovery14d55114-49a3-4596-85af-789741e6b2f2
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