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Comparisons of the effects of systemic administration of L-thyroxine and doxycycline on orthodontically induced root resorption in rats

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dc.contributor.authorBaysal, Asli
dc.contributor.authorUysal, Tancan
dc.contributor.authorOzdamar, Saim
dc.contributor.authorKurt, Bulent
dc.contributor.authorKurt, GÖKMEN
dc.contributor.authorGunhan, Omer
dc.contributor.institutionauthorKURT, GÖKMEN
dc.date.accessioned2020-10-29T20:30:06Z
dc.date.available2020-10-29T20:30:06Z
dc.date.issued2010-10-01T00:00:00Z
dc.description.abstractThe aim of this study was to histologically evaluate and compare the effects of the systemic administration of l-thyroxine (TX) and doxycycline (DX) on orthodontically induced root resorption, Twenty-eight male 50- to 60-day-old Wistar rats were used. Seven rats served as the baseline control. Seven animals received TX (20 mu g/kg bodyweight/day) and seven DX (1.2 mg/kg bodyweight/day), by means of a mini-osmotic pump implanted subcutaneously. Seven rats were separated as a sham, in order to evaluate the pure effect of the surgical procedure on the animals- health. Tooth movement (TM) was achieved with a continuous force of 50 g by placing Elgiloy coil springs between the right maxillary first molar and incisors for 14 days. The animals were sacrificed and specimens containing the appliance and maxillary tooth-bearing segments were processed for light microscopy. The surface area of root resorption lacunae was measured histomorphometrically using digital photomicrographs. To evaluate the resorptive changes on the molar root surface of each group, scanning electron microscopy (SEM) examinations were also carried out. Statistical evaluation of root resorption percentages was performed using Kruskal-Wallis analysis of variance test. Multiple comparisons were determined by the Student-Newman- Keuls method. The level of significance was set at P < 0.05.
dc.identifier.citationBaysal A., Uysal T., Ozdamar S., Kurt B., Kurt G., Gunhan O., -Comparisons of the effects of systemic administration of L-thyroxine and doxycycline on orthodontically induced root resorption in rats-, EUROPEAN JOURNAL OF ORTHODONTICS, cilt.32, ss.496-504, 2010
dc.identifier.doi10.1093/ejo/cjp124
dc.identifier.scopus77957790613
dc.identifier.urihttp://hdl.handle.net/20.500.12645/26078
dc.identifier.wosWOS:000282426900003
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleComparisons of the effects of systemic administration of L-thyroxine and doxycycline on orthodontically induced root resorption in rats
dc.typeArticle
dspace.entity.typePublication
local.avesis.id6d2304d4-6116-42dd-8f80-acad689e8cbe
local.publication.isinternational1
relation.isAuthorOfPublication3e64bd84-5cc2-4d20-a9d6-bbda78ee6d9f
relation.isAuthorOfPublication.latestForDiscovery3e64bd84-5cc2-4d20-a9d6-bbda78ee6d9f
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