Investigation of Associated Diseases in Acute Myocardial Infarction and Heart Failure: Metabolomic Insights

Abstract

Aim: Cardiovascular diseases (CVDs) are among the most common causes of death world-wide. Acute myocardial infarction (AMI) and heart failure (HF) are the most common CVDs, and the development of HF after AMI is common. The aim of our study was to determine the metabolic profile in the serum of patients with AMI/HF and to correlate metabolites with comorbidities. Materials and Methods: The study included 30 AMI and 30 HF patients admitted to Emergency Medicine Service who met the inclusion criteria. Serum samples were collected and analysed using liquid chromatography-high resolution mass spectrometry (LC-HRMS). Data were analysed using TidyMass and MetaboAnalyst. Results: LC-HRMS analysis of AMI and HF revealed metabolites that may be directly associated with pancreatic cancer, colon cancer, renal failure and uremia. These metabolites were involved in energy metabolism, lipid metabolism, and nucleotide metabolism. In addition, the metabolite N,N-dimethyldodecylamine N-oxide was found to be elevated in HF, compared to AMI. Conclusion: This study sheds light on metabolic changes in AMI/HF patients. It particularly highlights the metabolite relationship between cancer and kidney pathologies and CVDs. It points out that polypharmacy observed in HF may increase the accumulation of possibly hamful chemicals in the body.